1-Boc-2-Methylpiperazine Chemical Properties

Boiling point:

268.7±15.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

pka

8.49±0.40(Predicted)

color 

Colourless

CAS DataBase Reference

120737-78-2(CAS DataBase Reference)

Safety Information

RIDADR 

2735

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

2933599590

1-Boc-2-Methylpiperazine Usage And Synthesis

Uses

tert-Butyl 2-methylpiperazine-1-carboxylate is a useful reagent used in the synthesis of anthrafuran carboxamides with antitumor properties.

Synthesis

General procedure for the synthesis of tert-butyl 2-methylpiperazine-1-carboxylate from the compound (CAS: 120737-77-1): a mixture of tert-butyl (RS)-4-benzyl-2-methylpiperazine-1-carboxylate (3.41 g, 11.7 mmol), ethanol (125 mL), and Pearlman's catalyst (0.854 g, 6.08 mmol) was was hydrogenated overnight at 36 psi pressure at ambient temperature. Upon completion of the reaction, the mixture was filtered and the solids were washed sequentially with ethanol, dichloromethane (DCM) and methanol (MeOH). The filtrate and washings were combined, concentrated in vacuum, redissolved in dichloromethane, filtered again and concentrated in vacuum to give tert-butyl 2-methylpiperazine-1-carboxylate as a beige oil (2.0 g, 86% yield). The nuclear magnetic resonance (NMR) spectrum of the product was in agreement with the data reported in the literature (J. Org. Chem. 1995, 60, 4183).

References

[1] Patent: WO2007/135427, 2007, A1. Location in patent: Page/Page column 31
[2] Patent: US4880808, 1989, A

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