Imidocarb dipropionate Chemical Properties

Melting point:

205 °C (dec.)(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly, Heated), Methanol (Slightly)

form 

Solid

color 

White to Off-White

InChI

InChI=1S/C19H20N6O.C3H6O2/c26-19(24-15-5-1-3-13(11-15)17-20-7-8-21-17)25-16-6-2-4-14(12-16)18-22-9-10-23-18;1-2-3(4)5/h1-6,11-12H,7-10H2,(H,20,21)(H,22,23)(H2,24,25,26);2H2,1H3,(H,4,5)

InChIKey

AFGQXWSHYUHHNV-UHFFFAOYSA-N

SMILES

C(=O)(O)CC.N(C1=CC=CC(C2NCCN=2)=C1)C(=O)NC1C=CC=C(C2NCCN=2)C=1

CAS DataBase Reference

55750-06-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29332900

MSDS

• Language:English Provider:SigmaAldrich

Imidocarb dipropionate Usage And Synthesis

Description

Imidocarb dipropionate is a propionate salt of imidazobenzuron,  a potent antiprotozoal agent. It is commonly used in animals like horses, where it is found to be effective in inhibiting the Theileria equi strains causing infections.

Chemical Properties

White or off white crystalline powder

Uses

Imidocarb dipropionate is an antibiotic and diaminide of the carbanilide series of antiprotozoal compounds. It is used for the treatment and prevention of various diseases caused by Babesiosis, Pyriformes, Trypanosomes, Erythrocytes, Marginal Edge Worms and Taylor Worms.

Indications

For the treatment of dogs with clinical signs of babesiosis and/or demonstrated Babesia organisms in the blood.

Definition

Imidocarb dipropionate (Carbesia?, Carbésia?, Forray?, Imidox?, Imizol?) is a carbanilide derivative with antiprotozoal activity, marketed only for veterinary use. It is the most commonly used drug against Hepatozoon infections, and it also is used for the treatment of Trypanosoma brucei and Babesia ovis. Its mode of action is uncertain, but it has been suggested that it acts against T. brucei by interfering with polyamine production and against B. ovis by blocking the entrance of inositol into erythrocytes. Imidocarb dipropionate is eliminated via urine and feces. It is usually administered as the dipropionate salt and is commercially available in injectable formulations for s.c. or i.m. administration.

Side effects

Imidocarb dipropionate may display severe adverse effects, from pain at the site of infection, vomiting, diarrhea, agitation, lethargy, periorbital swelling, and acute renal tubular necrosis or hepatic necrosis.

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