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Benzimidazole

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Benzimidazole Basic information

Product Name:
Benzimidazole
Synonyms:
  • TIMTEC-BB SBB004294
  • N,N'-O-PHENYLENEFORMAMIDINE
  • 1,3-BENZODIAZOLE
  • 1H-BENZIMIDAZOLE
  • 1H-BENZO[D]IMIDAZOLE
  • AKOS BBS-00004349
  • BENZIMIDAZOLE
  • 1,3-Diazaindene
CAS:
51-17-2
MF:
C7H6N2
MW:
118.14
EINECS:
200-081-4
Product Categories:
  • BENZIMIDAZOLE
  • Pharmaceutical Intermediates
  • Intermediates
  • Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines
  • Imidazol&Benzimidazole
  • Imidaxoles
  • Pharmaceutical intermediate
  • A group of systemic fungicides benzimidazoles
Mol File:
51-17-2.mol
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Benzimidazole Chemical Properties

Melting point:
169-171 °C(lit.)
Boiling point:
360 °C
Density 
1.1151 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
360°C
storage temp. 
Store below +30°C.
solubility 
xylene: soluble1g in 2g (boiling)(lit.)
pka
5.532(at 25℃)
form 
Crystalline Powder or Crystals
color 
Beige to brown
Water Solubility 
sparingly soluble
λmax
271nm(MeOH)(lit.)
Merck 
14,1081
BRN 
109682
Stability:
Stable. Combustible. Incompatible with strong oxidising agents.
InChIKey
HYZJCKYKOHLVJF-UHFFFAOYSA-N
CAS DataBase Reference
51-17-2(CAS DataBase Reference)
NIST Chemistry Reference
1H-Benzimidazole(51-17-2)
EPA Substance Registry System
Benzimidazole (51-17-2)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-24/25
WGK Germany 
3
RTECS 
DD5425000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29339990
Hazardous Substances Data
51-17-2(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: 2910mg/kg

MSDS

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Benzimidazole Usage And Synthesis

Chemical Properties

white crystals

Uses

Usually used as template compound in the preparation of molecularly imprinted polymer via electropolymerization and electrodeposition of pyrrole on a pencil graphite electrode,and also used in the preparation of benzimidazolium surfactant, 1-hexadecyl-1H-benzimidazole.

General Description

White tabular crystals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

An amine. Neutralizes acids to form salts plus water. These acid-base reactions are exothermic. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. May be shock sensitive.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzimidazole emits highly toxic fumes.

Fire Hazard

Flash point data for Benzimidazole are not available. Benzimidazole is probably combustible.

Pharmacology

The mode of action of benzimidazoles has been described in several comprehensive reviews (1,32,33). The primary mode of action of benzimidazoles has been identified as the specific binding to the β-subunit of fungal tubulin and, consequently, an interference with microtubule assembly. Microtubules are major components of the fungal cytoskeleton and are involved in meiosis and mitosis, both of which are blocked in the presence of benzimidazoles.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits highly toxic fumes of NOx.

Purification Methods

It crystallises from water or aqueous EtOH (charcoal) and is dried at 100o for 12hours. [Beilstein 23 H 131, 23/6 V 196.]

BenzimidazoleSupplier

Shenzhen Vtolo Chemicals Co., Ltd. Gold
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13534282526
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Hebei Dj Yan Chemical Co., Ltd. Gold
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J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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INTATRADE GmbH
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+49 3493/605464
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sales@intatrade.de