2-Chlorobenzimidazole Chemical Properties

Melting point:

207-211 °C (lit.)

Boiling point:

250.67°C (rough estimate)

Density 

1.2763 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

9.81±0.10(Predicted)

form 

Crystalline Powder

color 

Beige to brown

Water Solubility 

Insoluble in water.

Sensitive 

Moisture Sensitive

BRN 

116526

InChI

InChI=1S/C7H5ClN2/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H,9,10)

InChIKey

AYPSHJCKSDNETA-UHFFFAOYSA-N

SMILES

C1(Cl)NC2=CC=CC=C2N=1

CAS DataBase Reference

4857-06-1(CAS DataBase Reference)

NIST Chemistry Reference

2-Chlorobenzimidazole(4857-06-1)

EPA Substance Registry System

1H-Benzimidazole, 2-chloro- (4857-06-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29332900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Chlorobenzimidazole Usage And Synthesis

Chemical Properties

BEIGE TO BROWN CRYSTALLINE POWDER

Uses

2-Chlorobenzimidazole is mainly used for the synthesis of medicine and as an intermediate in organic synthesis.

Application

2-Chlorobenzimidazole can be used to synthesize the following:
1-methyl-2-chlorobenzimidazole via reaction with dimethyl sulfate
1-ethyl-2-chlorobenzimidazole via reaction with diethyl sulfate
1-benzyl-2-chlorobenzimidazole via reaction with benzyl chloride
2-chloro-4,5,6,7-tetrabromobenzimidazole via bromination with bromine
It may be used as a building block to synthesize 4-amino-6-benzimidazole-pyrimidines.

General Description

2-Chlorobenzimidazole can be synthesized by reacting benzimidazole-2-one with phosphoryl chloride in the presence of phenol.

2-Chlorobenzimidazole(4857-06-1)Related Product Information

• Phenformin
• 2-Chloromethylbenzimidazole
• Benzimidazole
• 2-Methylbenzimidazole
• 2-Aminobenzimidazole
• 2-Hydroxybenzimidazole
• Chlorobenzimidazole,5-CHLOROBENZIMIDAZOLE,5-CHLOROBENZIMIDAZOLE (6-) 95+%
• Difluorochloromethane
• 2-CHLORO-5,6-DIMETHYLBENZIMIDAZOLE
• 2,5-DICHLOROBENZIMIDAZOLE
• 1-(4-Fluorobenzyl)-2-chlorobenzimidazole
• 5,6-DICHLORO-2-METHYLBENZIMIDAZOLE
• 2-METHYL-5-CHLOROBENZIMIDAZOLE
• 2,5,6-TRICHLORO-1H-BENZIMIDAZOLE
• 5,6-Dichloro-1-ethyl-2-methylbenzimidazole
• FENBENDAZOLE RELATED COMPOUND BMETHYL [5(6)CHLOROBENZIMIDAZOLE-2-YL) CARBAMATE USP STANDARD
• 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
• 1-(2-CHLOROPHENYL)IMIDAZOLE