2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Chemical Properties

Melting point:

261-263 °C(lit.)

Boiling point:

309.4±44.0 °C(Predicted)

Density 

1.2425 (rough estimate)

vapor pressure 

0.001Pa at 25℃

refractive index 

1.5690 (estimate)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Sparingly)

form 

Powder

pka

10.13±0.30(Predicted)

color 

Off-white to light yellow-brown

Water Solubility 

insoluble

Sensitive 

Air Sensitive

BRN 

3605123

LogP

1.52-2.399

CAS DataBase Reference

37052-78-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-37-22

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29332900

MSDS

• Language:English Provider:5-Methoxy-2-benzimidazolethiol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Usage And Synthesis

Description

2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfonyl]-1H-benzimidazole, 5-methoxy-2[[(4-methoxy-3, 5-dimethylpyridin-2-yl-1-oxide) methyl] sulfonyl]-1H-benzimidazole as well as tris[μ-1,2-bis(diphenylphosphino)ethane]-1:2κ2P:P′;1:3κ2P:P′;2:3κ2P:P′-di-μ-bromido-1:2κ4Br:Br-bromido-3κBr-tricopper(I) acetone hemisolvate. Furthermore, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole1. Finally, it acts as an intermediate for manufacture of the anti-ulcer drug Omeprazole.

Chemical Properties

off-white to light yellowish-brown powder

Uses

Reagent used in the synthesis of COX-2 inhibitors

Uses

2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole. Further, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole.

Uses

5-Methoxy-2-benzimidazolethiol may be used in the preparation of compounds present as contaminants in omeprazole, such as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole. It may be used in the synthesis of tris[μ-1,2-bis(diphenylphosphino)ethane]-1:2κ²P:P′;1:3κ²P:P′;2:3κ²P:P′-di-μ-bromido-1:2κ⁴Br:Br-bromido-3κBr-tricopper(I) acetone hemisolvate.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Flammability and Explosibility

Not classified

2-MERCAPTO-5-METHOXYBENZIMIDAZOLE(37052-78-1)Related Product Information

• 2-Ethylhexyl mercaptoacetate
• Mercaptoacetic acid
• 2-Mercaptobenzimidazole
• 2-Methoxyethanol
• Benzimidazole
• 2-Methylbenzimidazole
• 3-Mercaptopropionic acid
• Ufiprazole
• OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
• Calcium thioglycolate
• Omeprazole
• 5-METHOXY-2-[((4-METHOXY-3,5-DIMETHYL-1-OXIDO-2-PYRIDINYL)METHYL)SULFINYL]-BENZIMIDAZOLE
• Esomeprazole Impurity 3
• (S)-4-Desmethoxy-4-chloro Omeprazole
• 4-Hydroxy Omeprazole
• Omeprazole EP Impurity F
• Omeprazole Sulfone N-Oxide
• EsoMeprazole related substance H431/41