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Ufiprazole

Basic information Synthesis Safety Supplier Related

Ufiprazole Basic information

Product Name:
Ufiprazole
Synonyms:
  • 5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL THIO-1H-BENZIMIDAZOLE
  • 5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYLMERCAPTOBENZIMIDAZOLE
  • 5-METHOXY-2-[[(3,5-DIMETHYL-4-METHOXY PYRIDINYL)-METHYL]THIO]-1H-BENZIMIDAZOLE
  • 2-[(4-METHOXYETHOXY-3,5-DIMETHYL-2-PYRIDINYL)-METHYLTHIO]-5-METHOXYBENZIMIDAZOLE
  • 2-{[(3,5-dimethyl-4-methoxy-2-pyridinyl)-methyl]-thio}-5-methoxy-1h-benzimidazole
  • OMEPRAZOLE SULPHIDE
  • H 168/22
  • ufiprazole
CAS:
73590-85-9
MF:
C17H19N3O2S
MW:
329.42
EINECS:
615-997-3
Product Categories:
  • zjh
  • Inhibitors
  • (intermediate of lamivudine)
  • Intermediates & Fine Chemicals
  • Metabolites
  • Pharmaceuticals
  • Various Metabolites and Impurities
  • 73590-85-9
Mol File:
73590-85-9.mol
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Ufiprazole Chemical Properties

Melting point:
122.0 to 126.0 °C
Boiling point:
539.7±60.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.81±0.10(Predicted)
form 
Solid
color 
White to Off-White
λmax
307nm(MeOH)(lit.)
InChI
InChI=1S/C17H19N3O2S/c1-10-8-18-15(11(2)16(10)22-4)9-23-17-19-13-6-5-12(21-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChIKey
XURCIPRUUASYLR-UHFFFAOYSA-N
SMILES
C1(SCC2=NC=C(C)C(OC)=C2C)NC2=CC(OC)=CC=C2N=1
CAS DataBase Reference
73590-85-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29339900
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Ufiprazole Usage And Synthesis

Synthesis

Ufiprazole can be synthesized by the condensation reaction of 2-mercapto-5-methoxybenzimidazole and 2-chloromethyl-4-methoxy-3,5-lutidine.

Description

Omeprazole sulfide is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazole . As a degradation product, it is reported to be a direct-acting inhibitor of cytochrome P450 2C19 in pooled human liver microsomes (IC50 = 9.7 μM).

Uses

Omeprazole Sulfide (Esomeprazol EP Impurity C(Omeprazole EP Impurity C)) is a metabolite of Omeprazole.

Definition

ChEBI: Omeprazole sulfide is a member of benzimidazoles.

Biological Activity

Ufiprazole (Omeprazole sulfide) is an intermediate in the production of gastric proton pump inhibitors omeprazole and esomeprazole.

Ufiprazole Preparation Products And Raw materials

Raw materials

UfiprazoleSupplier

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