3,5-Dimethyl-4-methoxy-2-pyridinemethanol Chemical Properties

Melting point:

56.5-60.5 °C(lit.)

Boiling point:

115-135 °C(Press: 0.01 Torr)

Density 

1.092±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly)

form 

Solid

pka

13.27±0.10(Predicted)

color 

Off-White

InChI

InChI=1S/C9H13NO2/c1-6-4-10-8(5-11)7(2)9(6)12-3/h4,11H,5H2,1-3H3

InChIKey

PSEPRWKZZJWRCB-UHFFFAOYSA-N

SMILES

C1(CO)=NC=C(C)C(OC)=C1C

CAS DataBase Reference

86604-78-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich

3,5-Dimethyl-4-methoxy-2-pyridinemethanol Usage And Synthesis

Chemical Properties

White to light brown powder or crystal

Uses

(4-Methoxy-3,5-dimethylpyridin-2-yl)methanol can be used as wear-resistant rubber.

General Description

4-Methoxy-3,5-dimethyl-2-pyridinemethanol is a pyridine derivative.

Synthesis

General procedure for the synthesis of 4-methoxy-3,5-dimethyl-2-hydroxymethylpyridine from 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride: 80 g of 2-chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride was taken and 300 ml of methanol and 150 ml of water were added followed by 5.4 g of potassium iodide and 40.4 g of sodium hydroxide. The mixture was stirred and heated to reflux and the reaction lasted for 4 hours. Upon completion of the reaction, the methanol was removed by rotary evaporator. To the residue, 300 ml of drinking water was added, followed by extraction with dichloromethane (150 ml each time, 3 times). The organic phases were combined, washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. Finally, the organic phase was concentrated to give 50.0 g of a red oily liquid in 83.0% yield.

References

[1] Patent: CN107382963, 2017, A. Location in patent: Paragraph 0013; 0017; 0021

3,5-Dimethyl-4-methoxy-2-pyridinemethanol(86604-78-6)Related Product Information

• 4-Methoxypyridine
• Dimethyl sulfoxide
• Poly(dimethylsiloxane)
• 2,5-Dimethylpyridine
• N,N-Dimethylformamide
• DIMETHYLAMINOPYRIDINE, POLYMER-BOUND
• 2-Methoxyethanol
• 2,6-Lutidine
• 2-(Hydroxymethyl)pyridine
• Dimethyl phthalate
• Dimethyl carbonate
• 4-Methylpyridine
• Dimethyl ether
• 3,5-Lutidine
• ETHANE
• Dimethyl fumarate
• N,N-Dimethylacetamide
• Clopidol