2-Bromopropionic acid Chemical Properties

Melting point:

25.7°C

Boiling point:

203 °C (lit.)

Density 

1.7 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.475(lit.)

Flash point:

212 °F

storage temp. 

room temp

form 

Liquid After Melting

pka

pK1: 2.971 (25°C)

Specific Gravity

1.7

color 

Clear colorless to yellow

Water Solubility 

soluble

BRN 

605451

Dielectric constant

11.0

NIST Chemistry Reference

2-Bromopropanoic acid(598-72-1)

EPA Substance Registry System

Propanoic acid, 2-bromo- (598-72-1)

Safety Information

Hazard Codes 

C,Xi,F

Risk Statements 

22-34-40-36/37/38-38-11

Safety Statements 

26-36/37/39-45-36-16-24-9

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

RTECS 

UA2451715

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29159080

MSDS

• Language:English Provider:DL-2-Bromopropionic
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Bromopropionic acid Usage And Synthesis

Chemical Properties

clear colorless to yellowish liquid after melting. soluble in water, miscible with alcohol, ether, chloroform and benzene.

Uses

It is employed as pharmaceutical and agrochemical intermediate. It is used as an alkylation agent for mercaptans and other sulfur containing compounds.

Uses

2-Bromopropionic Acid is a versatile reactant used in emulsion polymerization in the preparation of reversible addition-fragmentation chain transfer (RAFT) agent.

Application

2-bromopropionic acid is an organic synthesis intermediate, used in the production of herbicides quizalofop-ethyl, napropamide, fenthiaprop and fungicides metalaxyl, benalaxyl, procymidone, etc., used in the synthesis of pharmaceutical intermediates body alanine.

Preparation

2-Bromopropionic acid is obtained by bromination of propionic acid. Add propionic acid and phosphorus trichloride to the reaction kettle, keep the temperature at 80°C, slowly add bromine to the reaction solution dropwise, and heat up to 85°C after the addition of bromine, and raise the temperature to 100°C when the color of bromine disappears completely, it takes about 2~3h, and then the bromine and hydrobromic acid are recovered under reduced pressure, and then the finished product is obtained by distillation under reduced pressure.

Synthesis Reference(s)

Tetrahedron Letters, 13, p. 4067, 1972 DOI: 10.1016/S0040-4039(01)94239-X

2-Bromopropionic acid(598-72-1)Related Product Information

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