Basic information Description References Safety Supplier Related
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L-Alanine

Basic information Description References Safety Supplier Related

L-Alanine Basic information

Product Name:
L-Alanine
Synonyms:
  • (S)-2-Aminopropanoic acid
  • (s)-2-aminopropanoicacid
  • Aspartic Acid Impurity 6
  • Tenofovir Impurity 80
  • (S)-2-Aminopropansαure
  • (S)-2-Aminopropionsαure
  • 2-Aminopropanoic acid
  • 2-Aminopropanoicacid
CAS:
56-41-7
MF:
C3H7NO2
MW:
89.09
EINECS:
200-273-8
Product Categories:
  • Amino Acids
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  • AStable Isotopes
  • Stable Isotopes
  • GABA/Glycine receptor
  • bio-chemical
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  • alanine
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  • Food & Feed ADDITIVES
  • Amino Acids
  • Alanine [Ala, A]
  • Amino Acids and Derivatives
  • alpha-Amino Acids
  • Biochemistry
  • Nutritional Supplements
  • L-Amino Acids
  • amino
  • bc0001
  • 56-41-7
Mol File:
56-41-7.mol
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L-Alanine Chemical Properties

Melting point:
314.5 °C
alpha 
14.5 º (c=10,6N HCl,dry sub.)
Boiling point:
212.9±23.0 °C(Predicted)
Density 
1,432 g/cm3
refractive index 
1.4650 (estimate)
FEMA 
3818 | DL-ALANINE
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
pka
2.34(at 25℃)
color 
White to almost white
PH
5.5-6.5 (100g/l, H2O, 20℃)
Odor
odorless
Odor Type
odorless
optical activity
[α]20/D +14.0±1°, c = 5% in 5 M HCl
Water Solubility 
166.5 g/L (25 ºC)
λmax
λ: 260 nm Amax: ≤0.03
λ: 280 nm Amax: ≤0.02
Merck 
14,204
BRN 
1720248
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
QNAYBMKLOCPYGJ-REOHCLBHSA-N
LogP
-0.68
CAS DataBase Reference
56-41-7(CAS DataBase Reference)
NIST Chemistry Reference
Alanine(56-41-7)
EPA Substance Registry System
L-Alanine (56-41-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
AY2990000
10
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29224995
Hazardous Substances Data
56-41-7(Hazardous Substances Data)

MSDS

  • Language:English Provider:Ala
  • Language:English Provider:SigmaAldrich
  • Language:English Provider:ACROS
  • Language:English Provider:ALFA
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L-Alanine Usage And Synthesis

Description

Alanine (also called 2-aminopropanoic acid, α-aminopropanoic acid) is an amino acid that helps the body convert the simple glucose into energy and eliminate excess toxins from the liver. Amino acids are the building blocks of important proteins and are key to building strong and healthy muscles. Alanine belongs to non-essential amino acids, which can be synthesized by the body. However, all amino acids may become essential if the body is unable to produce them. People with low-protein diets or eating disorders, liver disease, diabetes, or genetic conditions that cause Urea Cycle Disorders (UCDs) may need to take alanine supplements to avoid a deficiency.  Alanine has been shown to help protect cells from being damaged during intense aerobic activity when the body cannibalizes muscle protein to produce energy. Alanine is used to support prostate health and is important for the regulation of insulin.
L-alanine is the L-enantiomer of alanine. L-alanine is utilized in clinical nutrition as a component for parenteral and enteral nutrition. L-alanine plays a key role in transferring nitrogen from tissue sites to the liver. L-Alanine is widely used as nutrition supplements, as sweetener and flavor enhancer in the food industry, as flavor enhancer and preservative in the beverage industry, as intermediate for medicine manufacturing in pharmaceutical, as nutritional supplement and sour corrective agent in agriculture/animal feed, and as intermediate in manufacturing of various organic chemicals.

References

[1] http://www.ajiaminoscience.com/products/manufactured_products/l-amino_acids/L-Alanine.aspx
[2] http://www.foodchemadditives.com/applications-uses/1500
[3] http://www.vitaminstuff.com/amino-acid-alanine.html

Description

L-Alanine is a non-essential amino acid. It is produced by direct β-decarboxylation of L-aspartate by L-aspartate β-decarboxylase or transamination of pyruvate in the glucose-alanine cycle and is a precursor for gluconeogenesis. Dysregulation of L-alanine metabolism is associated with various disease states, including diabetes, metabolic syndrome, ketotic hypoglycemia, and acquired acute lactic acidosis.

Chemical Properties

A white, odorless powder having a sweet taste

Chemical Properties

White crystalline powder

Physical properties

pI 6.01, dissociation constants: pK1 2.34, pK2 9.69.

Occurrence

Natural constituent of protein in plants and animals; found in apple, beef, carob, pea, soybean, wine and zucchini

Uses

L-Alanine plays a vital role in glucose-alanine cycle between tissue and liver. It is used for protein construction as well as involved in the metabolism of tryptophan and vitamin pyridoxine. It provides energy for muscles and central nervous system in order to strengthen the immune system. It helps in the metabolism of sugars and organic acids, and enhances the germination rates of Bacillus subtilis spores. It also displays a cholesterol-reducing effect in animals.

Uses

Alanine is an amino acid that can act as a skin-conditioning agent. It is usually used in combination with other amino acids.

Definition

ChEBI: The L-enantiomer of alanine.

Production Methods

L -Alanine is industrially produced from L -aspartic acid by means of immobilized Pseudomonas dacunhae cells in a pressurized bioreactor. An alanine racemase-deficient mutant of Arthro-bacter oxydans was reported, that produces75 g/L L -alanine from glucose with a yield of 52% and 95% e.e. A small amount of L -alanine is still isolated from protein hydrolysates.

Preparation

Anthrobacter oxydans HAP-1 hyper produces DL-alanine in a nongrowth-associated manner.

General Description

L-Alanine, a non-essential amino acid,?is produced enzymatically from?L-aspartate using aspartate β-decarboxylase.?It is the smallest among all the amino acids.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

L-Alanine is a nonessential amino acid, which is highly concentrated in muscle. It is a key player in the Glucose-Alanine cycle, which enables the removal of pyruvate and glutamate from muscle to the liver. Once in the liver, glucose is regenerated from pyruvate and returned to the muscle while glutamate ultimately participates in the urea cycle to form urea. The Glucose-Alanine cycle aides to conserve ATP in muscle for muscle contraction, while the energy burden of gluconeogenesis is imposed upon the liver. Alanine inhibits pyruvate kinase to regulate gluconeogenesis and glycolysis in order to maintain glucose homeostasis during starvation. Alanine prevents hepatic autophagy. Alanine formation is a result of transamination of glutamate and pyruvate.

Safety Profile

Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

Purification Methods

Crystallise alanine from H2O or aqueous EtOH, i.e. crystallise it from 25% EtOH in water, or recrystallise it from 62.5% EtOH, wash it with EtOH and dry it to constant weight in vacuo over P2O5. [Gutter & Kegeles J Am Chem Soc 75 3893 1953, Walsh J Biol Chem 264 2394 1989.] 2,2'-Iminodipropionic acid is a likely impurity. [Beilstein 4 IV 2480. 2481.]

L-AlanineSupplier

Hebei Lihua Biotechnology Co. , Ltd. Gold
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Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
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Wuxi Bikang Bioengineering Co., Ltd Gold
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Zhengzhou Yuhe Food Additive Co. LTD Gold
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Hubei Hongjing Chemical Co., Ltd. Gold
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027-82333386 13669024603
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