3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Chemical Properties

Boiling point:

432.1±45.0 °C(Predicted)

Density 

1.08±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 18 mg/mL

form 

solid

pka

3.08±0.40(Predicted)

color 

off-white

Safety Information

WGK Germany 

3

3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Usage And Synthesis

Uses

C75 has been used:

• as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
• as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
• as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide

Definition

ChEBI: 4-methylene-2-octyl-5-oxo-3-oxolanecarboxylic acid is a gamma-lactone.

Biochem/physiol Actions

C75 helps to increase the cancer‐killing capability of ionizing radiation.

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