D-(-)-MANDELIC ACID BENZYL ESTER Chemical Properties

Melting point:

104-107 °C(lit.)

Boiling point:

387℃

Density 

1.204

refractive index 

-34 ° (C=1, CH3CN)

Flash point:

163℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml

form 

powder to crystal

pka

12.15±0.20(Predicted)

color 

White to Almost white

optical activity

[α]25/D 55°, c = 1 in chloroform

CAS DataBase Reference

97415-09-3

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29181990

MSDS

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D-(-)-MANDELIC ACID BENZYL ESTER Usage And Synthesis

Description

(R)-benzyl Mandelate is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

Benzyl (R)-(-)-mandelate can be employed as reactant to synthesize:

• (S)-α-Hydroxy-N-(2-phenylethyl)benzenepropanamide (α-hydroxyamides) by enzyme catalyzed amidation reaction.
• Optically pure (R)- monomethyl esters of 3-[(tert-butyldimethylsilyl)oxy]pentanedioic acid, which is employed in the preparation of HMG-CoA reductase inhibitors.
• O-Ibuprofenylmandelic acid via acylation reaction with optically active ibuprofen and subsequent hydrogenation.
• Benzyl (R)-2-fluoro-2-phenylacetate via deoxyfluorination of alcohols using AlkylFluor.

Uses

D-(-)-Mandelic Acid Benzyl Ester is a useful reagent for the preparation of a pharmaceutical composition for treating atopic dermatitis.

D-(-)-MANDELIC ACID BENZYL ESTER(97415-09-3)Related Product Information

• L-(+)-MANDELIC ACID BENZYL ESTER
• PHENYL ACETATE
• (S)-(+)-Mandelic acid
• Mandelic acid
• DL-MANDELIC ACID BENZYL ESTER 98+%,mandelic acid benzyl ester
• D-LACTIC ACID-BENZYL ESTER
• BENZYL PHENYLACETATE
• Benzyl lactate
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• DL-MANDELIC ACID BENZYL ESTER
• D-(-)-MANDELIC ACID BENZYL ESTER