(R)-(-)-2-Chloromandelic acid Chemical Properties

Melting point:

119-121 °C(lit.)

alpha 

-125 º (c=3, H2O)

Boiling point:

266.91°C (rough estimate)

Density 

1.48

vapor pressure 

0Pa at 25℃

refractive index 

-124.5 ° (C=3, H2O)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Methanol

pka

3.30±0.10(Predicted)

form 

Solid

color 

Off-White

optical activity

[α]23/D 126°, c = 3 in H2O

BRN 

2693370

LogP

1.51 at 23℃

Surface tension

48.7mN/m at 1g/L and 20℃

CAS DataBase Reference

52950-18-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-43-41

Safety Statements 

37/39-26-24/25-36-36/37/39

WGK Germany 

3

HS Code 

29181990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

(R)-(-)-2-Chloromandelic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

Clopidogrel intermediate.

Synthesis

First, 150 mL of toluene was added to a flask equipped with a stirrer and an internal thermometer. Under constant stirring, 0.09 g (0.08 x 10^-3 mol) of the (R,R)-VO salen complex of Example 1 and 21.1 g (0.15 mol) of freshly prepared 2-chlorobenzaldehyde were added sequentially. Subsequently, 10.1 g (0.375 mol) of hydrocyanic acid was added all at once. The resulting dark green homogeneous solution was stirred for 24 h at room temperature in a closed apparatus. The conversion was analyzed by gas chromatography (GC) to be 98% and the enantiomeric excess (ee) value of (S)-2-chloromandelate cyanohydrin was 73%.

References

[1] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[2] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[3] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[4] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[5] Patent: US2004/236129, 2004, A1. Location in patent: Page 4

(R)-(-)-2-Chloromandelic acid(52950-18-2)Related Product Information

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