(S)-2-Chloromandelic acid Chemical Properties

Melting point:

118-121 °C(lit.)

alpha 

124 º (c=3,H2O)

Boiling point:

350.3±27.0 °C(Predicted)

Density 

1.468±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Methanol, Water

form 

Powder

pka

3.30±0.10(Predicted)

color 

White to pale brown

CAS DataBase Reference

52950-19-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26-36

WGK Germany 

3

HS Code 

29181990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

(S)-2-Chloromandelic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

(S)-2-Chloromandelic acid can be used for chiral resolutions.

Synthesis

First, 150 mL of toluene was added to a flask equipped with a stirrer and an internal thermometer. Under constant stirring, 0.09 g (0.08 x 10^-3 mol) of the (R,R)-VO salen complex of Example 1 and 21.1 g (0.15 mol) of freshly prepared 2-chlorobenzaldehyde were added sequentially. Subsequently, 10.1 g (0.375 mol) of hydrocyanic acid was added all at once. The dark green homogeneous solution formed was stirred for 24 h at room temperature in a closed apparatus. The conversion was analyzed by gas chromatography (GC) and was 98%; the enantiomeric excess (ee) value of (S)-2-chloromandelate cyanohydrin was 73%.

References

[1] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[2] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[3] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[4] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[5] Patent: US2004/236129, 2004, A1. Location in patent: Page 4

(S)-2-Chloromandelic acid(52950-19-3)Related Product Information

• 2-Chlorobenzyl chloride
• (S)-(+)-Mandelic acid
• 2-Methylbenzyl chloride
• Mandelic acid
• alpha-Chloro-o-fluorotoluene
• Ethyl 2-(Chlorosulfonyl)acetate
• 2-Chloroaniline
• Folic acid
• Polyoxyethylene dioleate ether
• Allethrin
• Phosphinothricin
• 1-Chloropinacolone
• Methyl Oleate
• POE (2) OLEYL AMINE
• Citric acid
• Ascoric Acid
• 2-Aminobenzylchloride
• m-Chloromandelic acid,3-CHLOROMANDELIC ACID