Dicentrin Chemical Properties

Melting point:

177-178℃

Boiling point:

481℃

Density 

1.266

refractive index 

1.6250 (estimate)

Flash point:

143℃

storage temp. 

4°C, protect from light

solubility 

Soluble in DMSO

pka

6.65±0.20(Predicted)

form 

Solid

color 

Off-white to light brown

InChI

InChI=1S/C20H21NO4/c1-21-5-4-11-7-17-20(25-10-24-17)19-13-9-16(23-3)15(22-2)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m0/s1

InChIKey

YJWBWQWUHVXPNC-AWEZNQCLSA-N

SMILES

N1(C)[C@]2([H])C3=C(C4=C(C=C3CC1)OCO4)C1=CC(OC)=C(OC)C=C1C2

Dicentrin Usage And Synthesis

Description

D-Dicentrine is an aporphinic alkaloid found in several plant species, mainly from family Lauraceae, including Lindera megaphylla. D-Dicentrine shows antinociceptive activity in a mouse model of pain. It probably acts via a TRPA1-dependent mechanism. D-Dicentrine is an alpha 1-adrenoceptor antagonist effective against human hyperplastic prostates.

Anti-cancer Activity

D-Dicentrine, a naturally occurring aporphine type isoquinoline alkaloid, isolated from the root of Lindera megaphylla Hemsl. (Lauraceae), was evaluated for its potential anti-cancer activity. Huang RL etc. found d-dicentrine significantly inhibited the growth of human hepatoma cell line HuH-7 by delaying its doubling time in tissue culture. An in vitro colony forming assay showed that d-dicentrine decreased the colony formation efficiency in both hepatoma cell lines, HuH-7 and MS-G2, used in our study.

Uses

d-Dicentrine is a natural aporphine alkaloid extracted from the root of L. megaphylla which displays antitumor effects through inhibition of topoisomerase II.

Definition

ChEBI: Dicentrine is an aporphine alkaloid.

IC 50

α adrenergic receptor

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