Oosponol
Oosponol Basic information
- Product Name:
- Oosponol
- Synonyms:
-
- Oosponol
- 4-(1-Oxo-2-hydroxyethyl)-8-hydroxyisocoumarin
- 4-Glycolyl-8-hydroxyisocoumarin
- 8-Hydroxy-4-(hydroxyacetyl)-1H-2-benzopyran-1-one
- Lenzitin
- Brn 1287762
- Isocoumarin, 4-glycolyl-8-hydroxy-
- CAS:
- 146-04-3
- MW:
- 0
- Mol File:
- 146-04-3.mol
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Oosponol Chemical Properties
- LogP
- 0.789 (est)
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Oosponol Usage And Synthesis
Uses
Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi[1][2].
in vivo
Oosponol (6.25 mg/kg, 3.1 mg/kg, ip, Once) can lower blood pressure in spontaneously hypertensive rats model[1].
| Animal Model: | Spontaneously hypertensive rats[1] |
| Dosage: | 6.25 mg/kg, 3.1 mg/kg |
| Administration: | Intraperitoneal injection, once. |
| Result: | The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm[1]. |
| Animal Model: | Spontaneously hypertensive rats[1] |
| Dosage: | 6.25 mg/kg, 3.1 mg/kg |
| Administration: | Intraperitoneal injection, once. |
| Result: | The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm. |
References
[1] Umezawa H, et al.. Dopamine -hydroxylase inhibitor produced by Gloeophyllum striatum and its identity with oosponol. J Antibiot (Tokyo). 1972 Apr;25(4):239-42. DOI:10.7164/antibiotics.25.239
[2] Sonnenbichler J,et al. Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells. Eur J Biochem. 1997 May 15;246(1):45-9. DOI:10.1111/j.1432-1033.1997.t01-2-00045.x
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