4-Methylumbelliferylb-D-galactopyranoside-6-sulphatesodiumsalt Chemical Properties

Melting point:

196-198?C

storage temp. 

-20°C Freezer, Under Inert Atmosphere

solubility 

Methanol (Slightly, Sonicated), Water (Slightly)

form 

Solid

color 

White to Off-White

Stability:

-20?C Freezer, Under Inert Atmosphere

Safety Information

HS Code 

2932209090

4-Methylumbelliferylb-D-galactopyranoside-6-sulphatesodiumsalt Usage And Synthesis

Description

4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity. 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient. 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.

Chemical Properties

White Solid

Uses

Used for the determination of galactose-6-sulphate sulphatase activity. Used in the diagnosis of Mucopolysaccharidosis IV A.

Uses

4-Methylumbelliferylb-D-galactopyranoside-6-sulphatesodiumsalt is used for the determination of galactose-6-sulphate sulphatase activity,it is used in the diagnosis of Mucopolysaccharidosis IV A.