12-((6-Deoxyhexopyranosyl)oxy)-1,10-dihydroxy-8-methyl-6H-benzo(d)naph tho(1,2-b)pyran-6-one Chemical Properties

Boiling point:

817.8±65.0 °C(Predicted)

Density 

1.570±0.06 g/cm3(Predicted)

pka

7.75±0.20(Predicted)

12-((6-Deoxyhexopyranosyl)oxy)-1,10-dihydroxy-8-methyl-6H-benzo(d)naph tho(1,2-b)pyran-6-one Usage And Synthesis

Uses

BE-12406B is an antitumor agent that can be found in the culture broth of a streptomycete. BE-12406B can inhibit the growth of Vincristine (HY-N0488)-resistant or Doxorubicin (HY-15142A)-resistant P388 murine leukemia cell lines as well as their parent sensitive cell line[1][2].

References

[1] Nakajima S, et, al. New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. II. Structure determination. J Antibiot (Tokyo). 1991 Oct;44(10):1061-4. DOI:10.7164/antibiotics.44.1061
[2] Kojiri K, et, al. New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1991 Oct;44(10):1054-60. DOI:10.7164/antibiotics.44.1054

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