Deoxynojirimycin hydrochloride Chemical Properties

Melting point:

195-196°C

storage temp. 

Inert atmosphere,2-8°C

solubility 

Water (Slightly)

form 

Powder

color 

White

Water Solubility 

Soluble in water at 20mg/ml

BRN 

3563225

Stability:

Hygroscopic

CAS DataBase Reference

73285-50-4

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26-36-24/25-22

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:SigmaAldrich

Deoxynojirimycin hydrochloride Usage And Synthesis

Description

1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of α- and β-glucosidase (IC₅₀s = 35 and 71 μM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.

Chemical Properties

White Crystalline Solid

Uses

natural chitin synthase inhibitor

General Description

Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc₃Man₉GlcNAc₂ in N-linked glycan biosynthesis.

Biochem/physiol Actions

Product does not compete with ATP.

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