Doxifluridine Chemical Properties

Melting point:

188-192 °C(lit.)

alpha 

D25 +18.4° (c = 0.419 in water)

Density 

1.3751 (estimate)

refractive index 

20 ° (C=1, H2O)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

7.4(at 25℃)

color 

White

Merck 

14,3437

CAS DataBase Reference

3094-09-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

2

RTECS 

YU7526000

Hazard Note 

Irritant

HazardClass 

IRRITANT, IRRITANT-HARMFUL

HS Code 

29349990

Toxicity

LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)

MSDS

• Language:English Provider:5-Fluoro-5′-deoxyuridine
• Language:English Provider:SigmaAldrich

Doxifluridine Usage And Synthesis

Description

Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.

Chemical Properties

White Solid

Originator

Hoffmann-LaRoche (USA)

Uses

A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity

Uses

An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine

Uses

antineoplastic, pyrimidine antimetabolite

Uses

5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.

Definition

ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.

brand name

Furtulon

Biochem/physiol Actions

Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

Doxifluridine(3094-09-5)Related Product Information

• 5-Fluorouridine
• Chenodeoxycholic acid
• 1-beta-D-Arabinofuranosyluracil
• Ursodeoxycholic acid
• 5-Fluorouracil
• DL-PHENYLEPHRINE HYDROCHLORIDE
• Trifluridine
• Floxuridine
• 3'-O-(5'-Deoxy-α-D-ribofuranosyl) Capecitabine
• 5'-Deoxy-5-fluorocytidine
• 2'-O-(5'-Deoxy-β-D-ribofuranosyl) Capecitabine
• 5'-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2',3'-diacetate
• CAPECITABINE related substance USP
• 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine
• alpha-Capecitabine
• 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine
• 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine
• uridine diphosphate glucose {= UDP-glucose}