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Dantrolene sodium salt

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Dantrolene sodium salt Basic information

Product Name:
Dantrolene sodium salt
Synonyms:
  • Dantrolene Sodium Salt 
  • 1-[[5-(p-Nitrophenyl)furfurylidene]amino]-hydantoin sodium salt anhydrous
  • DantroloneSodium
  • SODIUM DANTROLENE
  • 1-[[[5-(4-NITROPHENYL)-2-FURANYL]METHYLENE]AMINO]-2,4-IMIDAZOLINEDIONE SODIUM SALT
  • 1-[[[5-(4-NITROPHENYL)-2-FURANYL]-METHYLENE]IMINO]2,4-IMIDAZOLIDINEDIONE SODIUM SALT
  • 1-[(5-[P-NITROPHENYL]FURFURYLIDENE)-AMINO]HYDANTOIN SODIUM SALT
  • DANTRIUM
CAS:
14663-23-1
MF:
C14H11N4NaO5
MW:
338.25
EINECS:
238-706-8
Product Categories:
  • pharmacetical
  • API's
  • InsP3/Ryanodine receptor
  • Cardiovascular APIs
Mol File:
14663-23-1.mol
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Dantrolene sodium salt Chemical Properties

storage temp. 
Store at RT
solubility 
Soluble in DMSO (up to 3 mg/ml)
form 
Orange solid
color 
Orange
Merck 
14,2816
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
InChIKey
KSRLIXGNPXAZHD-HAZZGOGXSA-M
CAS DataBase Reference
14663-23-1(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
MU3875000
HS Code 
2942.00.3500

MSDS

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Dantrolene sodium salt Usage And Synthesis

Description

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.

Chemical Properties

mp 279-280C 3415821

Uses

Skeletal muscle relaxant;Blocker of Ca2+ release

Uses

Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.

Definition

ChEBI: The anhydrous sodium salt of dantrolene.

brand name

Dantrium (Procter & Gamble).

Biological Activity

Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

storage

Store at RT

References

1) Zhao?et al.?(2001),?Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem.,?276?13810 2) Frandsen and Schousboe (1992),?Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA,?89?2590 3) Muehlschlegel and Sims (2009),?Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care,?10?103 4) Lu?et al.?(2014),?A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA,?111?E5292

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