2-CHLOROISONICOTINAMIDE Chemical Properties

Melting point:

198 °C

Boiling point:

312.2±27.0 °C(Predicted)

Density 

1.381±0.06 g/cm3(Predicted)

storage temp. 

Store at room temperature

pka

14.37±0.50(Predicted)

form 

powder to crystal

color 

White to Orange to Green

CAS DataBase Reference

100859-84-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2933399990

MSDS

• Language:English Provider:ALFA

2-CHLOROISONICOTINAMIDE Usage And Synthesis

Synthesis

GENERAL STEPS: To a flame-dried, sealable 2-5 mL Pyrex reactor were added the solid reactants: 2-chloro-4-cyanopyridine (1.0 mmol) and Cs2CO3 (1.5 mmol). The reactor was sealed with a rubber septum and pyrrolidone (2 mL/mmol [0.5 M]) was injected through the septum. Subsequently, the rubber septum was replaced with a PTFE screw cap. After sealing the reactor, the reaction was heated at 130 °C for 2 hours. Upon completion of the reaction, the resulting suspension was cooled to room temperature, filtered through a diatomaceous earth pad, and eluted with a solvent mixture of CH2Cl2/MeOH (7:3) to remove inorganic salts. Finally, the filtrate was concentrated and the residue was purified by silica gel column chromatography to afford the target product 2-chloroisonicotinamide.

References

[1] Organic Letters, 2014, vol. 16, # 4, p. 1060 - 1063
[2] Green Chemistry, 2016, vol. 18, # 18, p. 4865 - 4870
[3] Green Chemistry, 2014, vol. 16, # 4, p. 2136 - 2141
[4] Tetrahedron Letters, 2012, vol. 53, # 23, p. 2860 - 2863

2-CHLOROISONICOTINAMIDE(100859-84-5)Related Product Information

• 2,6-Dichloroisonicotinamide
• 3-Chloroisonicotinamide
• N-Methyl-4-chloropyridine-2-carboxamide
• 4-Chloropyridine-2-carboxamide
• Nicotine
• 2-Chloropyridine
• N4-(4-METHYLPHENYL)-2-CHLOROISONICOTINAMIDE
• N-(2-Amino-4-methylpyridin-3-yl)-2-chloropyridine-3-carboxamide
• N'4-[2-(TRIFLUOROMETHYL)PHENYL]-2,6-DICHLOROPYRIDINE-4-CARBOHYDRAZIDE
• N'4-(2,6-DICHLOROBENZYLIDENE)-2,6-DICHLOROPYRIDINE-4-CARBOHYDRAZIDE
• N'4-(2-CHLORO-6-METHYLPHENYL)-2,6-DICHLOROPYRIDINE-4-CARBOHYDRAZIDE
• 6-(TERT-BUTYL)-4-CHLORO-2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDINE-1,3-DIONE
• N4-(3-ISOPROPOXYPHENYL)-2,6-DICHLOROISONICOTINAMIDE
• N4-[4-PHENYL-5-(TRIFLUOROMETHYL)-3-THIENYL]-2,6-DICHLOROISONICOTINAMIDE
• N'4-BENZYLIDENE-2,6-DICHLOROPYRIDINE-4-CARBOHYDRAZIDE
• N'4-(4-BROMO-3-CHLOROPHENYL)-2,6-DICHLOROPYRIDINE-4-CARBOHYDRAZIDE
• 2-benzyl-4-chloro-6-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1,3-dione
• N'1-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-3,4-DICHLOROBENZENE-1-SULFONOHYDRAZIDE