Basic information Safety Supplier Related

SDZ NVI-085

Basic information Safety Supplier Related

SDZ NVI-085 Basic information

Product Name:
SDZ NVI-085
Synonyms:
  • SDZ NVI-085
  • [4aR,(-)]-3,4,4aβ,5,10,10aα-Hexahydro-6-methoxy-4-methyl-9-methylthio-2H-naphth[2,3-b]-1,4-oxazine
  • naphtoxazine
  • 2H-Naphth[2,3-b]-1,4-oxazine, 3,4,4a,5,10,10a-hexahydro-6-methoxy-4-methyl-9-(methylthio)-, (4aR,10aR)-
CAS:
104195-17-7
MF:
C15H21NO2S
MW:
279.4
Mol File:
104195-17-7.mol
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SDZ NVI-085 Chemical Properties

Boiling point:
417.6±45.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
pka
7.45±0.20(Predicted)
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SDZ NVI-085 Usage And Synthesis

Description

SDZ-NVI-085, also known as Naphtoxazine, is an α1 adrenergic receptor agonist potentially for the treatment of cognitive disorders and major depressive disorder. SDZ-NVI-085 behaves as a competitive antagonist of 5-hydroxytryptamine. SDZ-NVI-085 shifted 5-HT concentration-effect curves to the right, in a concentration-dependent manner, and Schild regression gave a pA2 estimate of 8.0.

Uses

SDZ NVI 085 is a compound with CNS stimulatory effects, primarily through the α1-adrenoceptor subtype, with anti-cataplexy and anti-stroke activities. SDZ NVI 085 also has a significant alertness effect and can be used to study other types of excessive sleepiness[1].

References

[1] A Renaud, et al. Effects of SDZ NVI-085, a putative subtype-selective α1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep. European journal of pharmacology 205.1 (1991): 11-16. DOI:10.1016/0014-2999(91)90763-g

SDZ NVI-085Supplier

TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Hangzhou MolCore BioPharmatech Co.,Ltd.
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+86-057181025280; +8617767106207
Email
sales@molcore.com
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SDZ NVI-085(104195-17-7)Related Product Information