sesaminol Chemical Properties

Boiling point:

504.7±50.0 °C(Predicted)

Density 

1.456±0.06 g/cm3(Predicted)

pka

9.69±0.20(Predicted)

sesaminol Usage And Synthesis

Uses

Sesaminol is an orally active activator for Nrf2-ARE pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease[1].

Definition

ChEBI: Sesaminol is a furofuran that is cis-tetrahydro-1H,3H-furo[3,4-c]furan substituted by a 6-hydroxy-1,3-benzodioxol-5-yl group at position 1S and a 1,3-benzodioxol-5-yl group at position 4S. It is metabolite found in sesame seeds. It has a role as a plant metabolite and an antioxidant. It is a member of benzodioxoles, a furofuran and an organic hydroxy compound.

References

[1] Kaji H, et al., Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway. Heliyon. 2020 Nov 2;6(11):e05342. DOI:10.1016/j.heliyon.2020.e05342

sesaminol(74061-79-3)Related Product Information

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