Sesamol
Sesamol Basic information
- Product Name:
- Sesamol
- Synonyms:
-
- 4-Hydroxy-1,2-Methylenedioxybenzene
- NSC 59256
- 5-Hydroxy-1,3-benzodioxole 3,4-Methylenedioxyphenol
- 3,4-METHYLENEDIOXYPHENOL FOR SYNTHESIS
- 1,2,4-Benzenetriol Methylene ether
- 1,3-Benzodioxol-5-ol, 9CI
- 3,4-(methylenedioxy)-pheno
- Methylene ether of oxyhydroquinone
- CAS:
- 533-31-3
- MF:
- C7H6O3
- MW:
- 138.12
- EINECS:
- 208-561-5
- Product Categories:
-
- API intermediates
- Aromatic Phenols
- Phenoles and thiophenoles
- Building Blocks
- C6 to C8
- Phenols
- Chemical Synthesis
- Organic Building Blocks
- Oxygen Compounds
- bc0001
- Mol File:
- 533-31-3.mol
Sesamol Chemical Properties
- Melting point:
- 62-65 °C (lit.)
- Boiling point:
- 113-116°C 2mm
- Density
- 1.2112 (rough estimate)
- refractive index
- 1.4850 (estimate)
- Flash point:
- 113-116°C/2mm
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform, Methanol
- pka
- 10.08±0.20(Predicted)
- form
- crystalline
- color
- off-white to tan
- Water Solubility
- slightly soluble
- Sensitive
- Light Sensitive
- BRN
- 127405
- InChIKey
- LUSZGTFNYDARNI-UHFFFAOYSA-N
- LogP
- 1.253 (est)
- CAS DataBase Reference
- 533-31-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,3-Benzodioxol-5-ol(533-31-3)
- EPA Substance Registry System
- Sesamol (533-31-3)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- SM0890000
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29329970
- Hazardous Substances Data
- 533-31-3(Hazardous Substances Data)
MSDS
- Language:English Provider:5-Benzodioxolol
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
Sesamol Usage And Synthesis
Description
Sesamol is found in sesame seeds and sesame oil. It is a well-known antioxidant. It has antioxidant, chemoprevention, antimutagenic, and antihepatotoxic activities and can induce the apoptosis of cancer and cardiovascular cells. It can be used in the synthesis of paroxetine.
Reference
- M. A. Ansari, Z. Fatima, S. Hameed, Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential, Journal of Pathogens, vol. 2014, Article ID 895193
- T. Geetha, B. Rohit, K. Pal, Sesamol: an efficient antioxidant with potential therapeutic benefits, Medicinal Chemistry, 2009, vol. 5, pp. 367-371
Chemical Properties
off-white to beige crystalline powder
Uses
Sesamol (Paroxetine Anhydrous EP Impurity B) is a natural component of sesame oil with antioxidant activity. Sesamol has potential protective effects against free radicals as well as some antifungal activity. Sesamol can also be used as an intermediate in the preparation of antidepressants such as Paroxetine (P205750).
Uses
Sesamol is a natural component of sesame oil with antioxidant activity. Sesamol has potential protective effects against free radicals as well as some antifungal activity. Sesamol can also be used as an intermediate in the preparation of antidepressants such as Paroxetine (P205750).
Definition
ChEBI: Sesamol is a member of benzodioxoles.
Synthesis Reference(s)
Tetrahedron Letters, 19, p. 3085, 1978 DOI: 10.1016/S0040-4039(01)94947-0
General Description
Sesamol, a principal phytophenol of sesame oil lignans, is typically used as a dietary compound.(10)
Sesamol Preparation Products And Raw materials
Raw materials
Preparation Products
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