BI-2493
BI-2493 Basic information
- Product Name:
- BI-2493
- Synonyms:
-
- Spiro[1,2-benzisoxazole-7(4H),4′(5′H)-benzo[b]thiophene]-3′-carbonitrile, 2′-amino-5,6,6′,7′-tetrahydro-3-[2-[(2S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-, (4′S)-
- bi-2493
- (S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile
- (S)-2-Amino-3'-[2-[(S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile
- (S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile
- CAS:
- 2937344-16-4
- MF:
- C24H27N7OS
- MW:
- 461.58
- Mol File:
- 2937344-16-4.mol
More
Less
BI-2493 Chemical Properties
- Boiling point:
- 774.2±70.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
- pka
- 8.62±0.40(Predicted)
- form
- Solid
- color
- Off-white to light yellow
More
Less
BI-2493 Usage And Synthesis
Uses
BI-2493 is a structural analog of BI-2865 and a highly selective pan-KRAS inhibitor. This compound can attenuate tumor growth and can also be used for cancer disease research.
in vivo
BI-2493 (90 mg/kg, p.o., twice daily for 21 days) exhibits tumor-suppressive activity in LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models[1].
| Animal Model: | LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models |
| Dosage: | 90 mg/kg |
| Administration: | Oral gavage (p.o.), twice daily for 21 days |
| Result: | Reduced tumor growth in mice carrying KRAS G12C, G12D, G12V, and A146V mutation models, without causing significant toxicity to the mice. |
IC 50
K-Ras WT
BI-2493Supplier
Shanghai Tachizaki Biomedical Research Center Gold
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Hangzhou J&H Chemical Co., Ltd.
- Tel
- 0571-87396432
- sales@jhechem.com
More
Less