nitroflurbiprofen
nitroflurbiprofen Basic information
- Product Name:
- nitroflurbiprofen
- Synonyms:
-
- nitroflurbiprofen
- HCT 1206
- Nitroxybutyl flurbiprofen
- [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, 4-(nitrooxy)butyl ester
- Cyclooxygenase,Inhibitor,COX,Nitroflurbiprofen,HCT-1206,inhibit,HCT1206
- Nitroflurbiprofen, 10 mM in DMSO
- CAS:
- 158836-71-6
- MF:
- C19H20FNO5
- MW:
- 361.36
- Mol File:
- 158836-71-6.mol
nitroflurbiprofen Chemical Properties
- Boiling point:
- 468.8±45.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Oil
- color
- Colorless to light yellow
nitroflurbiprofen Usage And Synthesis
Uses
Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
Definition
ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2.
in vivo
In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1].
IC 50
COX
References
[1] Laleman W, et al. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portalhypertension in rats. Gastroenterology. 2007 Feb;132(2):709-19. DOI:10.1053/j.gastro.2006.12.041
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nitroflurbiprofen(158836-71-6)Related Product Information
- [1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER
- (2-FLUORO-4-BIPHENYL)ACETIC ACID
- ETHYL P-TOLYLACETATE
- alpha-Methyl-4-biphenylacetic acid
- 1-Butyl nitrite
- Flurbiprofen
- 3-Fluoro-4-methylphenylacetic acid
- nitroflurbiprofen
- N-BUTYL NITRATE
- METHYL 3-FLUOROPHENYLACETATE
- 4-Biphenylacetic acid
- 3-FLUORO-4-METHYLPHENETHYL ALCOHOL
- 3-Fluorophenylacetic acid
- felbinacethyl