Bromoacetaldehyde Chemical Properties

Melting point:

136-138 °C

Boiling point:

109.35°C (estimate)

Density 

1.7515 (rough estimate)

refractive index 

1.4486 (estimate)

EPA Substance Registry System

Acetaldehyde, bromo- (17157-48-1)

Bromoacetaldehyde Usage And Synthesis

Uses

Bromoacetaldehyde can be used as an intermediate in pharmaceutical and chemical synthesis, mainly in laboratory research and development and chemical production processes.

Definition

ChEBI:2-Bromoacetaldehyde is an organobromine compound.

Synthesis

Preparation of Bromoacetaldehyde:1,4-dibromo-trans-2-butene(10g, 0.046 mol) was dissolved in dry CH2CI2 (100 ml) and cooled to -780℃ and ozone gas was bubbled until the blue color persisted (~30 min). A nitrogen stream was passed through the solution until the blue color disappeared, giving colorless solution. Triphenyl phosphine (12.9g, 0.046 mol) was added portion wise over a period EPO of 1 hr. The reaction mixture was brought to 0℃ and kept in the refrigerator for 15 hrs. The solvent (CH2CI2) was removed from the reaction mixture (without applying vacuum) and the thick residue was distilled at 400℃ under vacuum (1mm Hg), maintaining the temperature of the receiving flask at -780℃. (during distillation, special care was taken to maintain a cold water circulation (~0°C to - 50℃)). The bromoacetaldehyde(2.8g, yield = 50%) was obtained as a light yellow liquid.

Bromoacetaldehyde(17157-48-1)Related Product Information

• Ethyl 2-bromoisobutyrate
• 2-Bromopropionyl bromide
• tert-Butyl bromoacetate
• 2-Bromoisobutyryl Bromide
• DL-Ethyl 2-bromobutyrate
• Methyl 2-bromopropionate
• TRIMETHYLSILYL BROMOACETATE
• OXALYL BROMIDE
• Methyl bromoacetate
• Ethyl 2-bromoheptanoate
• Ethyl 2-bromohexanoate
• Bromoacetyl bromide
• 2-BROMO-2-PHENYLACETOPHENONE
• Benzyl 2-bromoacetate
• 2-Bromopropiophenone
• 2-BROMO-2-METHYLPROPIOPHENONE
• Ethyl 2-bromovalerate
• 2-Bromobutyryl bromide