4-Chlorophenylglyoxal hydrate Chemical Properties

Boiling point:

319.0±27.0 °C(Predicted)

Density 

1.454±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

10.42±0.41(Predicted)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2914790090

4-Chlorophenylglyoxal hydrate Usage And Synthesis

Synthesis

The general procedure for the synthesis of 4-chlorophenyl acetaldehyde hydrate from α-bromo-4-chloroacetophenone was as follows: 4'-chloro-2-bromoacetophenone (25.0 g, 107 mmol), water (1.92 mL, 107 mmol), and 47% hydrobromic acid (0.20 mL) were dissolved in dimethylsulfoxide (160 mL), and the reaction was stirred for 5 hr at 80 °C. Upon completion of the reaction, the reaction mixture was poured into water and the precipitate precipitated was filtered, washed with diethyl ether and dried to give 4-chloro-2,2-dihydroxyacetylbenzene (14.0 g, yield not indicated). The product was characterized by 1H NMR (300 MHz, CDCl3) with chemical shifts of δ 5.92 (1H, s), 7.45-7.52 (2H, m), 8.05-8.20 (2H, m).

References

[1] Patent: WO2004/85408, 2004, A1. Location in patent: Page 276

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