2-(Pyrimidin-5-yl)benzaldehyde Chemical Properties

Melting point:

119-120°C

Boiling point:

375.8±35.0 °C(Predicted)

Density 

1.205±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

1.63±0.10(Predicted)

form 

solid

CAS DataBase Reference

640769-71-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

26-36/37/39-39

Hazard Note 

Irritant

2-(Pyrimidin-5-yl)benzaldehyde Usage And Synthesis

Uses

2-(Pyrimidin-5-yl)benzaldehyde is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maitiμs lab th at promote site selectivity without the inclusion of additional synthetic steps.

2-(pyrimidin-5-yl)benzaldehyde is an effective TDG for meta directed C-H functionalization of amine substituted target compounds, with high selectivity.

2-(Pyrimidin-5-yl)benzaldehyde(640769-71-7)Related Product Information

• 4-Hydroxybenzaldehyde
• 2-Pyrimidinecarboxaldehyde
• 4-Dimethylaminobenzaldehyde
• 3-(Trifluoromethyl)benzaldehyde
• 3-Methoxybenzaldehyde
• 2-Nitrobenzaldehyde
• Pyrimidine-5-carboxaldehyde
• p-Anisaldehyde
• Benzaldehyde
• 2-(2-AMINOPYRIMIDIN-5-YL)BENZALDEHYDE
• 1-[2-(5-PYRIMIDINYL)PHENYL]ETHANONE
• 2-(Pyrimidin-5-yl)benzaldehyde