BOC-PHE-ONP Chemical Properties

Melting point:

127-128 °C

Boiling point:

558.4±50.0 °C(Predicted)

Density 

1.240±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

form 

Crystalline Powder

pka

10.83±0.46(Predicted)

color 

White

Sensitive 

Moisture Sensitive

CAS DataBase Reference

7535-56-0(CAS DataBase Reference)

Safety Information

WGK Germany 

3

F 

3-10-21

MSDS

• Language:English Provider:SigmaAldrich

BOC-PHE-ONP Usage And Synthesis

Uses

4-Nitrophenyl (tert-butoxycarbonyl)-L-phenylalaninate is a phenylalanine derivative[1].

Synthesis

The general procedure for the synthesis of Boc-L-aniline-4-nitrophenyl ester from 4-nitrophenol and Boc-L-phenylalanine is as follows: dissolve N-tert-butoxycarbonyl-L-phenylalanine (50 g) in dichloromethane (800 ml), stirring until completely dissolved. P-nitrophenol (39 g), 4-dimethylaminopyridine (DMAP, 3 g) and dicyclohexylcarbodiimide (DCC, 39 g) were added and the reaction was carried out for 5 hours at about 20°C. After completion of the reaction, the reaction mixture was filtered and the filtrate was evaporated. Ethanol was added to the residue and heated until complete dissolution, then slowly cooled to 20-30°C to allow the solid to precipitate gradually. Water (50 ml) was added and the mixture was cooled to 0°C and crystallized for 1 hour. The solid was collected by filtration to afford the target product Boc-L-aniline-4-nitrophenyl ester (62 g, 86.5% yield, 93% purity).

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-855. DOI:10.1080/10408398.2012.708368

BOC-PHE-ONP(7535-56-0)Related Product Information

• Aniline
• BOC-TYR-ONP
• N-Boc-L-Phenylalaninol
• BOC-ABU-ONP
• BOC-PHE-ONP
• BOC-L-ALANINE METHYL ESTER
• Phenylalanine-N-carboxylic acid dimethyl ester
• BOC-DL-PHENYLALANINE METHYL ESTER
• N-(tert-Butoxycarbonyl)-L-phenylalanine
• BOC-ALA-ONP
• BOC-GLY-ONP
• N-Boc-L-phenylalaninal
• 4-(3-phenylpropoxy)phenylamine
• BOC-O-BENZYL-L-TYROSINE 4-NITROPHENYL ESTER
• BOC-PHE-OME
• FOR-PHE-OME