5-Amino-6-chloro-3-pyridinecarboxylic acid methyl ester Chemical Properties

Boiling point:

328.2±37.0 °C(Predicted)

Density 

1.384±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

0.20±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

HS Code 

2933399990

5-Amino-6-chloro-3-pyridinecarboxylic acid methyl ester Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-amino-6-chloronicotinic acid methyl ester from 6-chloro-5-nitronicotinic acid: a suspension of methyl 6-chloro-5-nitronicotinic acid (1 eq.), iron powder (5.2 eq.) and NH4Cl (5.3 eq.) in methanol was heated and reacted for 2 hr at 75 °C. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad while hot and the filtrate was subsequently concentrated in vacuum to afford the target product methyl 5-amino-6-chloronicotinate in 56% yield.

References

[1] Patent: WO2010/71853, 2010, A1. Location in patent: Page/Page column 68
[2] Patent: WO2013/169704, 2013, A2. Location in patent: Paragraph 0290
[3] Patent: WO2015/95795, 2015, A1. Location in patent: Paragraph 0378

5-Amino-6-chloro-3-pyridinecarboxylic acid methyl ester(211915-96-7)Related Product Information

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