A-(METHYLTHIO)ACETAMIDE Chemical Properties

Melting point:

99-102℃

Boiling point:

259℃

Density 

1.132

Flash point:

110℃

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

15.65±0.40(Predicted)

color 

White to Almost white

CAS DataBase Reference

22551-24-2

Safety Information

HS Code 

2930.90.9250

A-(METHYLTHIO)ACETAMIDE Usage And Synthesis

Synthesis

Example 12 Preparation of 2-(methylthio)acetamide (compound of Formula III). 200 g of 2-(methylthio)acetic acid methyl ester was slowly added dropwise to 462.9 g (514.4 mL, 282%) of ammonium hydroxide solution at 20-25°C. The dropwise addition was controlled to be completed within 15 minutes. After the dropwise addition was completed, the reaction mixture was kept at this temperature and continued to be stirred for 2 hours (a white solid precipitated at the beginning of the reaction). Subsequently, the reaction suspension was cooled to 0-5°C and stirring was continued at this temperature for 2 hours to complete crystallization. The white solid product was collected by filtration and the resulting solid was resuspended and treated with 200 mL of 2-propanol for 30 minutes at 0-5 °C. The solid was again filtered, washed with 2-propanol and finally dried under vacuum at 40 °C to give white crystalline 2-(methylthio)acetamide (yield: 76.2%; GC purity: 99.9%).

References

[1] Patent: US2009/312575, 2009, A1. Location in patent: Page/Page column 6-7

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