Alizapride Chemical Properties

Melting point:

139°

Boiling point:

580.3±40.0 °C(Predicted)

Density 

1.224±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

7.09±0.40(Predicted)

CAS DataBase Reference

59338-93-1(CAS DataBase Reference)

Safety Information

Toxicity

LD50 i.v. in mice (5 days): 92.7 mg/kg (Bulteau)

Alizapride Usage And Synthesis

Originator

Plitican ,Delagrange ,France ,1981

Definition

ChEBI: 6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide is a member of benzotriazoles.

Manufacturing Process

38.6 g (0.2 mol) of 2-methoxy-4,5-azimidobenzoic acid were dissolved in anhydrous toluene and 56 g (0.4 mol) of 1-allyl-2-amino-methylpyrrolidine were added. The mixture was heated to 50°C and then 42 g (0.3 mol) of phosphoric anhydride were added. The mixture was warmed at reflux temperature for 3 hours and then cooled to 80°C. After adding water, the aqueous layer was alkalized. The crystals were filtered, washed with water and then dissolved in 450 ml of acetone. After crystallization, the product was 40.4 g (yield 65%) of N-(1'-allyl-2'-pyrrolidylmethyl)-2-methoxy-4,5- azimidobenzamide having a melting point of 139°C were obtained.

Therapeutic Function

Neuroleptic, Antiemetic

Alizapride(59338-93-1)Related Product Information

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