Fumonisin B2 Chemical Properties

Melting point:

<3200(dec)

Boiling point:

705.92°C (rough estimate)

Density 

1.2044 (rough estimate)

refractive index 

1.6630 (estimate)

Flash point:

6 °C

storage temp. 

-20°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

3?+-.0.23(Predicted)

form 

Off-white solid

color 

Off-White to Beige

Stability:

Hygroscopic

CAS DataBase Reference

116355-84-1

Safety Information

Hazard Codes 

T+,T,Xn,F

Risk Statements 

26/27/28-36/37/38-40-36-20/21/22-11

Safety Statements 

22-36/37/39-45-36/37-16-26

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

RTECS 

TZ8335000

HS Code 

29221990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Fumonisin B2 Usage And Synthesis

Description

Fumonisin B2 belongs to the family of toxins known as fumonisins. It is produced by several species of Fusarium molds primarily by Fusarium verticillioide. It is one of the major mycotoxin contaminant in corn and corn-based foods. Fumonisin B2 is a structural analog of fumonisin B1 but it is more cytotoxic than the latter and it inhibits sphinganine-N-acetyltransferase (ceramide synthase).
Fumonisin B2 is a carcinogenic mycotoxin generally present on corn based food and feed-stuff, which is produced by the fungus Fusarium verticillioides and Fusarium moniliforme. Fumonisin B2 can also be detected in the industrially important fungi, Aspergillus niger.

Chemical Properties

Pale Yellow Crystalline Solid

Uses

Fumonisin B2 is a minor analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. To date much of the research on the pharmacology of the fumonisins has focused on fumonisin B1. It is generally accepted that fumonisin B2 acts on ceramide biosynthesis, however, the pharmacology of the minor analogues is less well explored.

Uses

A mycotoxin produced by mold associated with corn. Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.

Uses

Contact herbicide used also to produce desiccation and defoliation

Definition

ChEBI: Fumonisin B2 is a fumonisin that is (2S,3S,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,14,15-triol in which the hydroxy groups at positions 14 and 15 have each been esterified by condensation with the 1-carboxy group of 3-carboxyglutaric acid (giving a 3-carboxyglutarate ester group with R configuration in each case). It has a role as an Aspergillus metabolite and a carcinogenic agent. It is a fumonisin, a primary amino compound, a diol and a diester.

General Description

Fumonisin B₂ (FB₂) is a diester of tricarballylic acid and polyhydric alcohols.. Fumonisins B₂ (FB₂) does not have one or more hydroxyl groups at the C5 or C10 positions.

Biochem/physiol Actions

Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.

Safety Profile

Fumonisin B2, a mycotoxin produced by Fusariummoniliforme in a variety of cereals, is a potent inhibitor of sphingosine N-acyltransferase (ceramidesynthase), blocking sphingolipid de novo synthesis. Fumonisin (FB) is a mycotoxin, a structurally similar bidentate compound composed of different polyhydric alcohols and propionic tricarboxylic acids, of which fumonisin B1 (FB1), fumonisin B2 (FB2) and fumonisin B3 (FB3) are the main components of contaminated food and its products, and a potential trigger for cancer, and has been declared by the International Agency for Research on Cancer as The International Agency for Research on Cancer has declared fumonisins as "Class 2B" toxicants (possible carcinogens to humans).

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