Basic information Safety Supplier Related

N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE

Basic information Safety Supplier Related

N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE Basic information

Product Name:
N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE
Synonyms:
  • N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE
  • ZM 226600
  • Propanamide, 3,3,3-trifluoro-2-hydroxy-2-methyl-N-[4-(phenylsulfonyl)phenyl]-
  • 3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(4-(phenylsulfonyl)phenyl)propanamide
  • ZM 226600, 10 mM in DMSO
CAS:
147695-92-9
MF:
C16H14F3NO4S
MW:
373.35
Mol File:
147695-92-9.mol
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N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE Chemical Properties

storage temp. 
Store at RT
solubility 
Soluble to 100 mM in DMSO
form 
Off-white solid.
color 
White to off-white
InChI
InChI=1S/C16H14F3NO4S/c1-15(22,16(17,18)19)14(21)20-11-7-9-13(10-8-11)25(23,24)12-5-3-2-4-6-12/h2-10,22H,1H3,(H,20,21)
InChIKey
LJLXQHHFAKVTNP-UHFFFAOYSA-N
SMILES
C(NC1=CC=C(S(C2=CC=CC=C2)(=O)=O)C=C1)(=O)C(O)(C)C(F)(F)F
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N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE Usage And Synthesis

Uses

ZM 226600, is a potent KIR (Kir6, KATP) channel opener (EC50 = 0.5 μM), devoid of antiandrogen properties.

Definition

ChEBI: N-[4-(benzenesulfonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide is an anilide.

in vivo

ZM226600 (10-1000 nmol/kg, i.v.) does not alter significantly the heart beats rate in anaesthetized rats[1].

N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDESupplier

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