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ZM 336372

Basic information Safety Supplier Related

ZM 336372 Basic information

Product Name:
ZM 336372
Synonyms:
  • N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE
  • ZM 336372
  • Zinc00581684
  • 3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE
  • 3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide
  • Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-
  • ZM 336372 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide
  • ZM 336372, >=98%
CAS:
208260-29-1
MF:
C23H23N3O3
MW:
389.45
Product Categories:
  • Inhibitors
  • MAPK
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • A potent and specific inhibitor of the protein kinase c-Raf.
  • Pharmaceuticals
Mol File:
208260-29-1.mol
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ZM 336372 Chemical Properties

Boiling point:
484.4±45.0 °C(Predicted)
Density 
1.298
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: >5mg/mL (warmed)
form 
powder
pka
8.31±0.15(Predicted)
color 
white to beige
Sensitive 
Light Sensitive
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Safety Information

WGK Germany 
3
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ZM 336372 Usage And Synthesis

Description

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

Uses

It is small molecule tyrosine kinase modulator.

Uses

It is small molecule tyrosine kinase modulator. ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines.

ZM 336372Supplier

Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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3bsc@sina.com
Chembest Research Laboratories Limited
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021-20908456-
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sales@BioChemBest.com
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
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21-57721279-
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sales@shydchem.com.cn