ZM 241385 Chemical Properties

Density 

1.59±0.1 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: >15mg/mL

pka

10.03±0.15(Predicted)

form 

powder

color 

white to tan

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

46

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

ZM 241385 Usage And Synthesis

Uses

ZM 241385 is a selective and potent Adenosine A2A-R antagonist.

Definition

ChEBI: 4-[2-[[7-amino-2-(2-furanyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]phenol is a diamino-1,3,5-triazine.

Biochem/physiol Actions

ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.

storage

Room temperature

ZM 241385(139180-30-6)Related Product Information

• ZM223
• ZM 39923 HYDROCHLORIDE
• ZM306416
• Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
• ZM 323881 hydrochloride
• ZM 447439
• ZM 336372
• ZM 39923 HCl
• ZM 306416
• (3H)-ZM 241385
• ZM 241385, [2-3H]
• 1H-1,2,4-Triazole-1-carboximidamide hydrochloride
• 1,3-DIMETHYL-1H-1,2,4-TRIAZOL-5-AMINE
• ZM 241385
• 7-Amino-s-triazolo[1,5-a]-s-triazine