ZM 306416 hydrochloride Chemical Properties

storage temp. 

RT

solubility 

Soluble in DMSO (up to 5 mg/ml).

form 

solid

color 

White

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

ZM 306416 hydrochloride Usage And Synthesis

Description

ZM-306416 (196603-47-1) is a VEGF receptor tyrosine kinase inhibitor with selectivity over FGFR-1 (KDR IC50 = 100 nM; FLT IC50 = 2 μM).

Uses

ZM 306416 Hydrochloride, is an inhibitor of tyrosine kinase RTK signaling pathway involved in anti-cancer agents. Anti-tumor, anti-metastatic agent.

IC 50

KDR: 100 nM (IC₅₀); Flt-1: 2000 nM (IC₅₀)

References

[1] LAURENT F. HENNEQUIN. Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 1999, 42 26: 5369-5389. DOI:10.1021/jm990345w

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