METHIOTHEPIN MALEATE
METHIOTHEPIN MALEATE Basic information
- Product Name:
- METHIOTHEPIN MALEATE
- Synonyms:
-
- RO 8-6837
- 1-(10,11-dihydro-8-methylthiodibenzo(b,f)thiepin-10-yl)-4-methyl-piperazin
- 8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepinmaleate
- f)thiepin,10,11-dihydro-10-(4-methylpiperazino)-8-methylthio-dibenzo(hyd
- f)thiepin,10,11-dihydro-8-methylthio-10-(4-methylpiperazino)-dibenzo(hyd
- metitepinmaleate
- Dibenzo(B,F)thiepin, 10,11-dihydro-10-(4-methylpiperazino)-8-methylthio-, hydrogen maleate
- Dibenzo(B,F)thiepin, 10,11-dihydro-8-methylthio-10-(4-methylpiperazino)-, hydrogen maleate
- CAS:
- 19728-88-2
- MF:
- C24H28N2O4S2
- MW:
- 472.62
- Mol File:
- 19728-88-2.mol
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METHIOTHEPIN MALEATE Chemical Properties
- Melting point:
- 171-173°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble to 100 mM in DMSO
- form
- Powder
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METHIOTHEPIN MALEATE Usage And Synthesis
Uses
Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist.
Uses
Biochemical tool in serotonin receptor binding studies.
Definition
ChEBI: A maleate salt obtained by reaction of methiothepin with one equivalent of maleic acid. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays ffinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
METHIOTHEPIN MALEATESupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
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BOC Sciences
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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- 18818260767
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