DIPROPYLENETRIAMINE Chemical Properties

Melting point:

−14 °C(lit.)

Boiling point:

151 °C50 mm Hg(lit.)

Density 

0.938 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.481(lit.)

Flash point:

245 °F

storage temp. 

2-8°C

Water Solubility 

Completely miscible in water

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

clear liquid

pka

pK1:8.02(＋2);pK2:9.70(＋1);pK3:10.70(0) (30°C)

color 

Colorless to Almost colorless

BRN 

1071254

Stability:

Air and light sensitive. Combustible. Incompatible with oxidizing agents.

LogP

-0.826 (est)

CAS DataBase Reference

56-18-8(CAS DataBase Reference)

EPA Substance Registry System

Norspermidine (56-18-8)

Safety Information

Hazard Codes 

T+,C

Risk Statements 

22-24-26-35-43-68-48/20/21

Safety Statements 

26-28-36/37/39-45

RIDADR 

UN 2269 8/PG 3

WGK Germany 

2

RTECS 

JL9450000

HazardClass 

8

PackingGroup 

III

HS Code 

29252900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

DIPROPYLENETRIAMINE Usage And Synthesis

Chemical Properties

colourless to yellow liquid

Uses

A structural homologue of the natural polyamine spermidine with antitumor activity that may make it useful as a antineoplastic agent.

Uses

Bis(3-aminopropyl)amine (BAPA) can be used:

• To synthesize chitosan based hydrogels having potential biomedical applications.
• For the functionalization of nanoparticles to yield terminal ?NH₂ groups for further modifications.
• As an internal dispersing agent for the synthesis of water-dispersible polyurethanes.
• As a ligand in the preparation of [Cu(bapa)]₂[Mo(CN)₈]·7H₂O photomagnetic coordination polymer.

Definition

ChEBI: Bis(3-aminopropyl)amine is a polyazaalkane. It has a role as an algal metabolite and a plant metabolite. It is a conjugate base of a bis(3-azaniumylpropyl)azanium.

Synthesis Reference(s)

The Journal of Organic Chemistry, 58, p. 3736, 1993 DOI: 10.1021/jo00066a028
Journal of the American Chemical Society, 105, p. 5002, 1983 DOI: 10.1021/ja00353a025

General Description

A colorless liquid. Less dense than water. Flash point of 170°F. Very irritating to skin and eyes, and may be toxic by ingestion. Used to make soaps, dyes, and pharmaceuticals.

Air & Water Reactions

Water soluble.

Reactivity Profile

DIPROPYLENETRIAMINE neutralize acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. DIPROPYLENETRIAMINE can react with oxidizing materials .

Hazard

Toxic by ingestion and inhalation; irritant.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by skin contact. Moderately toxic by ingestion. A skin and severe eye irritant. When heated to decomposition it emits toxic fumes of NO,. An explosive

Purification Methods

Dry the amine with Na and distil it under vacuum. [Beilstein 4 IV 1278.]

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