Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antineoplastic agents >  Antibiotics anticancer drugs >  ACLARUBICIN HYDROCHLORIDE

ACLARUBICIN HYDROCHLORIDE

Basic information Safety Supplier Related

ACLARUBICIN HYDROCHLORIDE Basic information

Product Name:
ACLARUBICIN HYDROCHLORIDE
Synonyms:
  • aclacinomycinahydrochloride
  • aclacinon
  • n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano
  • syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
  • ACLARUBICIN HYDROCHLORIDE
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, meth
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]-
CAS:
75443-99-1
MF:
C42H54ClNO15
MW:
848.33
EINECS:
278-209-3
Product Categories:
  • API
Mol File:
75443-99-1.mol
More
Less

ACLARUBICIN HYDROCHLORIDE Chemical Properties

Melting point:
151-153℃
Boiling point:
898℃
Flash point:
>110°(230°F)
storage temp. 
2-8°C
solubility 
Soluble in DMSO or DMF at 25mg/ml
form 
Solid
color 
Light yellow to yellow
More
Less

Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
3249
RTECS 
QI9283500
HazardClass 
6.1(a)
PackingGroup 
II
More
Less

ACLARUBICIN HYDROCHLORIDE Usage And Synthesis

Definition

ChEBI: Aclarubicin hydrochloride is an anthracycline.

Biological Activity

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) is a fluorescent molecule and the first non-peptidic inhibitor discovered to have discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. It is also a dual inhibitor of topoisomerase I and II (topoisomerase I and II). It is an effective anthracycline chemotherapeutic agent for blood cancer and solid tumor related research.

in vitro

Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .

in vivo

Aclarubicin hydrochloride(Aclacinomycin A) is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD 50 (76.5 mg/kg) is about twice the iv LD 50 (35.6 mg/kg) in mice [4 .
Aclacinomycin A ( 0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model [4 .

td>
Animal Model: DBA/2, CDF 1 ( BALB/c×DBA/2) mice with Leukemia P-388 [4 .
Dosage: 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
Administration: Intraperit oneal administration daily for 10 days starting 3 hr after transplantation.
Result: Inhibited tumor growth.

target

20S proteasome.
Topoisomerase I and II.

ACLARUBICIN HYDROCHLORIDESupplier

Shanghai Fuhe Chemistry Technology Co., Ltd.
Tel
0086-21-67651709
Email
cfx759@hotmail.com
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Email
2853530910@QQ.com
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Alfa Chemistry
Tel
Email
Info@alfa-chemistry.com
More
Less

ACLARUBICIN HYDROCHLORIDE(75443-99-1)Related Product Information