CLOFOCTOL Chemical Properties

Melting point:

78°

Boiling point:

447.7±40.0 °C(Predicted)

Density 

1.127±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:100.0(Max Conc. mg/mL);273.72(Max Conc. mM)

form 

Solid

pka

10.09±0.45(Predicted)

color 

White to off-white

Safety Information

WGK Germany 

2

RTECS 

SL0533000

Toxicity

LD50 orally in male rats: >4 g/kg (Debat)

MSDS

• Language:English Provider:SigmaAldrich

CLOFOCTOL Usage And Synthesis

Originator

Octofene,Debat,France,1978

Uses

antibacterial

Uses

Clofoctol is a bacteriostatic antibiotic used against gram-positive bacteria.

Definition

ChEBI: 2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol is a diarylmethane.

Manufacturing Process

The following were introduced into a 1 liter flask provided with a reflux condenser: 206 g (1 mol) of p-(1,1,3,3-tetramethylbutyl)-phenol, 147 g (0.75 mol) of 2,4-dichlorobenzyl chloride, 27 g (0.2 mol) of pure melted zinc chloride, and 750 ml of anhydrous chloroform.
The mixture was heated to reflux for 24 hours. The chloroformic reaction mixture was washed with water, and then dried over anhydrous sodium sulfate. The chloroform was evaporated off and the oil obtained was fractionally distilled under a pressure of 0.2 mm Hg. The fraction distilling at 140°C to 160°C, being the desired product indicated above, was collected and crystallized. Yield: 94 g (32% of theory); MP 78°C (after recrystallization in petroleum ether).

Therapeutic Function

Antiinfective, Bacteriostatic

CLOFOCTOL(37693-01-9)Related Product Information

• Clomifene
• 4-tert-Octylphenol
• CLOFOCTOL
• 2-METHYL-4-TERT-OCTYLPHENOL