CLOFOCTOL
CLOFOCTOL Basic information
- Product Name:
- CLOFOCTOL
- Synonyms:
-
- CLOFOCTOL
- 2-[2,4-DICHLOROBENZYL]-4-[1,1,3,3-TETRAMETHYLBUTYL]PHENOL
- 2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)-pheno
- 2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)phenol
- α-[2,4-Dichlorophenyl]-4-[1,1,3,3-tetramethylbutyl]-o-cresol
- Gramplus
- Octofene
- 2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
- CAS:
- 37693-01-9
- MF:
- C21H26Cl2O
- MW:
- 365.34
- EINECS:
- 253-632-6
- Product Categories:
-
- OCTOPHENE
- Mol File:
- 37693-01-9.mol
CLOFOCTOL Chemical Properties
- Melting point:
- 78°
- Boiling point:
- 447.7±40.0 °C(Predicted)
- Density
- 1.127±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);273.72(Max Conc. mM)
- pka
- 10.09±0.45(Predicted)
MSDS
- Language:English Provider:SigmaAldrich
CLOFOCTOL Usage And Synthesis
Originator
Octofene,Debat,France,1978
Uses
antibacterial
Uses
Clofoctol is a bacteriostatic antibiotic used against gram-positive bacteria.
Definition
ChEBI: 2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol is a diarylmethane.
Manufacturing Process
The following were introduced into a 1 liter flask provided with a reflux
condenser: 206 g (1 mol) of p-(1,1,3,3-tetramethylbutyl)-phenol, 147 g (0.75
mol) of 2,4-dichlorobenzyl chloride, 27 g (0.2 mol) of pure melted zinc
chloride, and 750 ml of anhydrous chloroform.
The mixture was heated to reflux for 24 hours. The chloroformic reaction
mixture was washed with water, and then dried over anhydrous sodium
sulfate. The chloroform was evaporated off and the oil obtained was
fractionally distilled under a pressure of 0.2 mm Hg. The fraction distilling at
140°C to 160°C, being the desired product indicated above, was collected and
crystallized. Yield: 94 g (32% of theory); MP 78°C (after recrystallization in
petroleum ether).
Therapeutic Function
Antiinfective, Bacteriostatic
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