Maxacalcitol
Maxacalcitol Basic information
- Product Name:
- Maxacalcitol
- Synonyms:
-
- MAXACALCITOL
- (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
- (5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10(19)-triene-1α,3β,25-triol
- 22-Oxa-1α,25-dihydroxycholecalciferol
- Oxacalcitriol
- (+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10(19)-triene-1,3-diol
- 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
- (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
- CAS:
- 103909-75-7
- MF:
- C26H42O4
- MW:
- 418.61
- EINECS:
- 234-317-2
- Product Categories:
-
- API
- Mol File:
- 103909-75-7.mol
Maxacalcitol Chemical Properties
- Melting point:
- 122°
- alpha
- D20 +49.4° (c = l.00 in ethanol)
- Boiling point:
- 581.4±50.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 14.43±0.40(Predicted)
- InChIKey
- DTXXSJZBSTYZKE-ZDQKKZTESA-N
- SMILES
- [C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@@H](OCCC(O)(C)C)C)/C(=C)[C@@H](O)C1
Maxacalcitol Usage And Synthesis
Description
Maxacalcitol is the third synthetic vitamin D analog, after paricalcitol and doxercalciferol, to be marketed for the treatment of secondary hyperparathyroidism (SHPT) associated with chronic renal failure. It is a new vitamin D3 derivative with an oxygen atom in 22-position as main structural feature (22-oxacalcitriol, OCT). This vitamin D receptor agonist has a strong inhibitory effect on synthesis and secretion of parathyroid hormone in the setting of severe parathyroid hyperplasia. Maxacalcitol induced only minor effects on calcium and phosphate metabolism unlike an agent such as 1, 25(OH)2D3 that produced hypercalcemia and hyperphosphatemia. Maxacalcitol is.
Originator
Chugai (Japan)
Uses
22-Oxacalcitriol is the noncalcemic analogue of vitamine D and was found to suppress parathyroid hormone synthesis and secretion.
Definition
ChEBI: Maxacalcitol is an organic molecular entity.
brand name
Prezios (Chugai Pharmaceutical Co., Ltd., Japan);Prezios, Oxarol.
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