2-Cyano-N,N-diethylacetamide Chemical Properties

Melting point:

121 °C

Boiling point:

114°C/4mmHg(lit.)

Density 

1.013 g/mL at 25 °C

refractive index 

n20/D1.466

Flash point:

>110℃

storage temp. 

2-8°C

solubility 

Chloroform, Ethyl Acetate, Tetrahydrofuran, Methanol

form 

Oil

pka

4.53±0.10(Predicted)

color 

Light Yellow to Light Brown

InChIKey

RYSHIRFTLKZVIH-UHFFFAOYSA-N

CAS DataBase Reference

26391-06-0(CAS DataBase Reference)

Safety Information

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2926907090

2-Cyano-N,N-diethylacetamide Usage And Synthesis

Chemical Properties

Pale Brown Oil

Uses

N,N-Diethyl-2-cyanoacetoamide can be used:

• To prepare N,N-diethyl 2-cyano-2-fluoro-2-phenylthioacetoamide, which is further used in the synthesis of various cyanofluoroamides.
• In the synthesis of entacapone, a catechol-O-methyltransferase inhibitor by reacting with 3,4-dihydroxy-5-nitrobenzaldehyde.
• As a building block in the synthesis of fluorophores, applicable as endoplasmic reticulum probes.

Definition

ChEBI: N,N-diethylcyanoacetamide is an aliphatic nitrile and a monocarboxylic acid amide.

2-Cyano-N,N-diethylacetamide(26391-06-0)Related Product Information

• 2-Cyanoacetamide
• Thioacetamide
• DIACETAMIDE
• Acetamide
• N,N-Diethylhydroxylamine
• N,N-Diethylethylenediamine
• N,N-Dimethylacetoacetamide
• Diethylacetamide
• N,N-Dimethylacetamide
• 7'-METHYL-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-6'-CARBONITRILE
• N-CYANOACETYLMORPHOLINE
• N-CYANOACETYLPYRROLIDINE
• 1-CYANOACETYLPIPERIDINE
• ETHYL 2-(6'-CYANO-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-7'-YL)ACETATE
• 7-METHYL-1,5-DIOXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-6-CARBONITRILE
• METHYL 6-CYANO-1-HYDROXY-7-METHYL-5-OXO-3,5-DIHYDROINDOLIZINE-2-CARBOXYLATE
• 6-(4-CHLOROPHENYL)-1-(3,4-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• 2-Cyano-N,N-diethylacetamide