2-MORPHOLINOBENZOIC ACID Chemical Properties

Melting point:

157 °C

Boiling point:

387.5±37.0 °C(Predicted)

Density 

1.253±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

2.67±0.36(Predicted)

Appearance

Light yellow to light brown Solid

CAS DataBase Reference

42106-48-9

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-37/39

Hazard Note 

Irritant

HS Code 

29349990

2-MORPHOLINOBENZOIC ACID Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

2-Morpholinobenzoic Acid is used in the preparation of amino acids as inhibitors of αvβ integrin and for treating fibrosis.

Synthesis

The general procedure for the synthesis of 2-(4-morpholinyl)benzoic acid from ethyl 2-morpholinobenzoate was as follows: referring to the method of Example 1e, ethyl 2-(morpholin-4-yl)-benzoate was reacted with 2 molar equivalents of sodium hydroxide in methanol solution. After completion of the reaction, the target product 2-(4-morpholinyl)benzoic acid was obtained after post-processing in 90% yield of the theoretical value. The Rf value of the product was 0.75 (silica gel plate; unfolding agent ratio dichloromethane/ethanol/ammonia = 8:4:0.2).

References

[1] Patent: US2003/162788, 2003, A1
[2] Patent: US2003/73836, 2003, A1
[3] Patent: EP1147095, 2004, B1. Location in patent: Page 68

2-MORPHOLINOBENZOIC ACID(42106-48-9)Related Product Information

• 2-MORPHOLINOBENZOIC ACID
• 3-MORPHOLINOBENZOIC ACID
• 4-(MORPHOLINOMETHYL)BENZOIC ACID
• 4-MORPHOLINOBENZOIC ACID
• 5-AMINO-2-MORPHOLIN-4-YL-BENZOIC ACID METHYL ESTER
• 2-MORPHOLIN-4-YL-5-(PIPERIDINE-1-SULFONYL)-BENZOIC ACID
• 2-MORPHOLINO-5-(1H-PYRROL-1-YL)BENZOIC ACID
• METHYL 2-MORPHOLINO-5-NITROBENZENECARBOXYLATE
• 5-AMINO-2-MORPHOLINOBENZOIC ACID
• 2-MORPHOLINO-5-NITROBENZOIC ACID
• METHYL 2-MORPHOLINOBENZOATE
• 2-MORPHOLIN-4-YL-BENZOIC ACID ETHYL ESTER
• 2-MORPHOLIN-4-YL-5-(MORPHOLIN-4-YLSULFONYL)BENZOIC ACID
• 5-[(DIMETHYLAMINO)SULFONYL]-2-MORPHOLIN-4-YLBENZOIC ACID
• 5-NITRO-2-(2,6-DIMETHYLMORPHOLIN-4-YL)BENZOIC ACID
• 2-FLUORO-4-MORPHOLINOBENZOIC ACID
• 2-Methoxy-4-Morpholinobenzoic Acid
• 2-MORPHOLIN-4-YL-5-(3-THIOPHEN-2-YL-ACRYLOYLAMINO)-BENZOIC ACID