2-Fluorobenzonitrile Chemical Properties

Melting point:

-13.7 °C

Boiling point:

90 °C21 mm Hg(lit.)

Density 

1.116 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.505(lit.)

Flash point:

165 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform

form 

Liquid

color 

Clear colorless to light brownish

Water Solubility 

Insoluble

BRN 

2042184

InChIKey

GDHXJNRAJRCGMX-UHFFFAOYSA-N

CAS DataBase Reference

394-47-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzonitrile, 2-fluoro-(394-47-8)

EPA Substance Registry System

Benzonitrile, 2-fluoro- (394-47-8)

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

22-37/38-41-36/37/38-20/21/22

Safety Statements 

26-39-36/37/39-36

RIDADR 

3276

WGK Germany 

3

Hazard Note 

Toxic

TSCA 

T

HazardClass 

IRRITANT, IRRITANT-HARMFUL

PackingGroup 

III

HS Code 

29269095

MSDS

• Language:English Provider:2-Fluorobenzonitrile
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Fluorobenzonitrile Usage And Synthesis

Synthesis

Tetramethylammonium fluoride (TMAF) has been found to be an effective fluorodenitration reagent. The good selectivity for the fluoroaromatic and not the phenol has been attributed to the stability of ion pairing between nitrite and tetramethylammonium ions. TMAF reacts with 2-nitrobenzonitrile to give a quantitative conversion to 2-fluorobenzonitrile.

Chemical Properties

colorless to light yellow liquid

Uses

2-Fluorobenzonitrile, also known as o-fluorobenzonitrile, is an organic aromatic fluoride. It has a wide range of applications in pharmaceuticals, pesticides, dyestuffs, etc. In the field of dyestuff, the introduction of fluorine atom makes the dyed products bright and colorful and less likely to fade, among other advantages.

Uses

2-Fluorobenzonitrile was used in the synthesis of :
3-amino-1,2-benzisoxazoles
6-(acetylaminomethyl)-3-amino-1,2-benzisoxazole
5-(4′-methyl [1, 1′-biphenyl]-2-yl)-1H-tetrazole
xanthone-iminium triflates

General Description

2-Fluorobenzonitrile reacts with lithium N,N-dialkylaminoborohydride reagent to yield 2-(N,N-dialkylamino)benzylamines.

2-Fluorobenzonitrile(394-47-8)Related Product Information

• 2-Fluoropropiophenone
• 2-Chlorobenzyl alcohol
• 2-Fluorobenzaldehyde
• 2-Bromofluorobenzene
• ETHYL 2-FLUOROBENZOATE
• 2-Fluorobenzoic acid
• 2-Chlorophenylacetic acid
• 2-Chloromandelic acid
• 2-Fluorophenylacetic acid
• 2'-Fluoroacetophenone
• 2-Chlorobenzonitrile
• 2'-Chloroacetophenone
• 2-Chlorobenzyl bromide
• 1-Fluoro-2-nitrobenzene
• 2-Chlorobenzaldehyde
• 2,6-Difluorobenzonitrile
• 2-Fluoro-6-methoxybenzonitrile
• 3,4,5,6-Tetrafluorophthalonitrile