3,4,5,6-Tetrafluorophthalonitrile Chemical Properties

Melting point:

81-86 °C(lit.)

Boiling point:

274.2±40.0 °C(Predicted)

Density 

1.54±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol,Acetone,Ethanol

form 

powder to crystal

color 

White to Almost white

InChI

InChI=1S/C8F4N2/c9-5-3(1-13)4(2-14)6(10)8(12)7(5)11

InChIKey

OFLRJMBSWDXSPG-UHFFFAOYSA-N

SMILES

C1(C#N)=C(F)C(F)=C(F)C(F)=C1C#N

CAS DataBase Reference

1835-65-0(CAS DataBase Reference)

NIST Chemistry Reference

Tetrafluorophthalonitrile(1835-65-0)

EPA Substance Registry System

Tetrafluorophthalonitrile (1835-65-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

RIDADR 

3439

WGK Germany 

3

Hazard Note 

Irritant/Lachrymator

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29269090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3,4,5,6-Tetrafluorophthalonitrile Usage And Synthesis

Chemical Properties

White powder

Uses

Tetrafluorophthalonitrile was used in the synthesis of dichloro-subphthalocyanine dimers.

General Description

Tetrafluorophthalonitrile reacts with:

• copper, copper (I) chloride or copper (II) chloride to yield copper (II) hexadecafluorophthalocyanine
• potassium salt of 2-hydroxyhexafluoro-2-propylbenzene to yield 2-phenyl-2-(3,4-dicyano- trifluorophenoxy) hexafluoropropane
• dipotassium salt of 1,3-bis(2-hdroxyhexafluoro-2- propyl) benzene to yield fluorinated phthalonitrile resins

Synthesis

Example A Synthesis of 3,4,5,6-tetrafluorophthalonitrile: Anhydrous potassium fluoride (11.0 kg) was added to a 50 gallon stainless steel reactor. The salt was dried at 115°-138°C for 48 hours under 28 inches of vacuum. After the salt was cooled to 100°C, cyclobutanesulfone (19 liters) and tetrachlorophthalonitrile (4.74 kg) were added sequentially. The mixture was heated to 156°C within 30 minutes with stirring, followed by continued heating at 135°-162°C for 2.5 hours with vigorous stirring. Upon completion of the reaction, the mixture was cooled to 31°C (taking 15 minutes) and ice (69 kg) and softened water (119 liters) were added. After stirring the resulting mixture for 1.5 hours, the crude product was collected by centrifugation and washed with softened water (120 liters). The crude product was retransferred to a 50-gallon stainless steel still with deionized water (100 liters). Steam distillation was performed until 80 liters of distillate were collected. The distillate was cooled to 0°-5°C and the product was collected by centrifugation. The crystals were washed with softened water (2 x 90 l) to give 2.82 kg of wet product (LOD 6.4%; calculated yield: 74%). A small amount of the sample was vacuum dried at room temperature for two days and the melting point was measured to be 81°-83°C.

References

[1] Patent: US4782180, 1988, A

3,4,5,6-Tetrafluorophthalonitrile(1835-65-0)Related Product Information

• o-Phenylenediamine
• o-Phthalaldehyde
• Phthalic anhydride
• 1,2-Dimethoxybenzene
• O-Phthalimide
• Potassium hydrogen phthalate
• Dibutyl phthalate
• Phthalonitrile
• PHTHALAMIDE
• 3-Fluorophthalic acid
• 3,4,5,6-Tetrachlorophthalonitrile
• 2-Cyanophenol
• Bis(2-ethylhexyl) phthalate
• Dimethyl phthalate
• 4-Aminophthalonitrile
• Phthalic acid
• 2,4,5,6-Tetrafluoroisophthalonitrile
• Phthaloyl dichloride