2-Fluorobenzoic acid Chemical Properties

Melting point:

122-125 °C (lit.)

Boiling point:

114 °C

Density 

1,46 g/cm³

storage temp. 

Sealed in dry,Room Temperature

solubility 

7.2g/l

form 

Crystalline Powder or Needles

pka

3.27(at 25℃)

color 

White to light yellow

Water Solubility 

Slightly soluble in water.

BRN 

971265

InChI

InChI=1S/C7H5FO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)

InChIKey

NSTREUWFTAOOKS-UHFFFAOYSA-N

SMILES

C(O)(=O)C1=CC=CC=C1F

CAS DataBase Reference

445-29-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzoic acid, 2-fluoro-(445-29-4)

EPA Substance Registry System

Benzoic acid, 2-fluoro- (445-29-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-36/37/38

Safety Statements 

22-26-28-24/25-37/39-36

WGK Germany 

3

RTECS 

DH0250000

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29163900

MSDS

• Language:English Provider:2-Fluorobenzoic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Fluorobenzoic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder. soluble in organic solvents such as benzene, toluene, ketone and ether.The corresponding 2-fluorobenzoyl chloride can be obtained by reacting 2-fluorobenzoic acid with an acid chloride agent such as SOCl2, PCl3, etc.

Uses

2-Fluorobenzoic acid is an intermediate of the fungicide tritriazole and meclofenamic acid.

Uses

2-Fluorobenzoic acid may be employed in the preparation of zaragozic acid A analogs. It is also used as an organic chemical synthesis intermediate.

Preparation

The preparation of 2-fluorobenzoic acid is based on anthranilic acid as raw material, adding anhydrous hydrogen fluoride and sodium nitrite in methoxyethyl methyl ether solvent for diazotization, refluxing for 3 hours, and post-processing to obtain the finished product.

Definition

ChEBI: 2-fluorobenzoic acid is a 2-halobenzoic acid that is benzoic acid carrying a fluoro substituent at position 2. It is a fluorobenzoic acid and a 2-halobenzoic acid. It is a conjugate acid of a 2-fluorobenzoate.

Purification Methods

Crystallise the acid from 50% aqueous EtOH, dilute HCl or *C6H6, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333. 9 III 1324, 9 IV 950.]

2-Fluorobenzoic acid(445-29-4)Related Product Information

• 2,6-Difluorobenzoic acid
• 3,4-Difluorobenzoic acid
• Diethyl phthalate
• 1,2-Difluorobenzene
• Potassium hydrogen phthalate
• Stearic acid
• 2-Fluorobenzonitrile
• 2,4-Difluorobenzoic acid
• Folic acid
• Bis(2-ethylhexyl) phthalate
• Citric acid
• Ethyl 2-(Chlorosulfonyl)acetate
• 2,4,5-Trifluorobenzoic acid
• 2-Iodobenzoic acid
• Phthalic acid
• 2-Fluoroanisole
• Dimethyl phthalate
• ETHYL 2-FLUOROBENZOATE