2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) Chemical Properties

Melting point:

117-119 °C

Boiling point:

518.4±50.0 °C(Predicted)

Density 

1.28

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol

form 

Solid

color 

Off-White to Light Grey

Stability:

Moisture Sensitive

InChI

InChI=1/C21H21ClO5/c1-13-3-7-15(8-4-13)20(23)25-12-18-17(11-19(22)26-18)27-21(24)16-9-5-14(2)6-10-16/h3-10,17-19H,11-12H2,1-2H3/t17-,18+,19+/s3

InChIKey

XJHDINDXQMZBKW-XUVXKRRUSA-N

SMILES

[C@@H]1(Cl)O[C@H](COC(=O)C2=CC=C(C)C=C2)[C@@H](OC(=O)C2=CC=C(C)C=C2)C1 |&1:0,3,15,r|

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29321900

MSDS

• Language:English Provider:SigmaAldrich

2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) Usage And Synthesis

Chemical Properties

White solid

Uses

Hoffer''s Chlorosugar is a synthetic precursor for ribose glycosides and ribonucleosides.

Synthesis

Under argon protection, (2R,3S)-5-methoxy-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate (50.0 g, 0.13 mol) was dissolved in glacial acetic acid (150 mL) and stirred at room temperature for 20 min. The reaction solution was cooled to 10-15 °C and a dioxane solution (150 mL, 0.6 mol) in 4 M HCl was slowly added dropwise for a controlled time of 5 min. After observing a light straw color to the solution, a small amount of 1-Α-chloro-3,5-di-O-tosyl-2-deoxy-D-ribofuranose crystal species was added and stirred briefly until a precipitate appeared. Stirring was stopped and the reaction mixture was allowed to stand for 40 minutes while being kept cool with an ice water bath. The white slurry was broken up by swirling the flask and quickly filtered. The resulting filter cake was washed with cold ether (3 x 30 mL) and dried under high vacuum to afford the target product 1-Α-chloro-3,5-di-O-p-toluoyl-2-deoxy-D-ribofuranose (34.1 g, 67% yield) as a white solid. The spectral data and analytical results of the product were in agreement with those reported in the literature. Thin layer chromatography (TLC) Rf value was 0.58 (Expanding agent: ethyl acetate-hexane, 1:2). Infrared spectra (IR, cm-1): 3030, 2951, 1708, 1276, 1178, 1099, 755. nuclear magnetic resonance hydrogen spectrum (1H NMR, 250.1 MHz, CDCl3): δ 2.41 (s, 3H, CH3), 2.42 (s, 3H, CH3), 2.74 (m, 1H, 2-CH), 2.84 (m 1H, 2-CH), 4.61 (dd, J=12.1,4.1 Hz, 1H, 5-CH), 4.66 (dd, J=12.1,4.1 Hz, 1H, 5-CH), 4.85 (m, 1H, 4-CH), 5.58 (m, 1H, 3-CH), 6.47 (d, J=4.2 Hz, 1H, 1-CH), 7.24 (d, J=8.3 Hz, 2H, 3,5-tol-CH), 7.26 (d, J=8.3 Hz, 2H, 3,5-tol-CH), 7.90 (d, J=8.3 Hz, 2H, 2,6-tol-CH), 7.99 (d, J=8.3 Hz, 2H, 2,6-tol-CH). Nuclear magnetic resonance carbon spectrum (13C NMR, 62.9 MHz, CDCl3): δ 21.70 (CH3), 21.71 (CH3), 44.54 (2-CH2), 63.51 (5-CH2), 73.56 (4-CH), 84.71 (3-CH), 95.3 (1-CH), 126.66 (C), 126.72 ( C), 129.19 (CH), 129.21 (CH), 129.63 (CH), 129.88 (CH), 144.07 (C), 144.30 (C), 166.07 (CO), 166.41 (CO). Mass spectra (EI): m/z (relative abundance) 353 ([M-Cl]+, 1), 252 (1), 216 (32), 136 (38), 119 (100), 91 (78), 81 (100), 65 (28), 53 (25), 39 (19). Calculated elemental analysis (C21H22ClO5): C, 64.8; H, 5.41. Measured values: C, 64.4; H, 5.39.

References

[1] Organic and Biomolecular Chemistry, 2003, vol. 1, # 13, p. 2267 - 2275
[2] Organic Letters, 2002, vol. 4, # 26, p. 4571 - 4574
[3] Journal of the Chinese Chemical Society, 1997, vol. 44, # 4, p. 413 - 416
[4] Arkivoc, 2017, vol. 2017, # 3, p. 87 - 104
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 8, p. 2044 - 2050

2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate)(4330-21-6)Related Product Information

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