Basic information Safety Supplier Related

7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

Basic information Safety Supplier Related

7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER Basic information

Product Name:
7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER
Synonyms:
  • 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER
  • Ethyl-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
  • 3-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-, ethyl ester
  • 3-Carbethoxy-4-hydroxy-7-chloroquinoline
  • Ethyl 4-hydroxy-7-chloroquinoline-3-carboxylate
  • 4-Hydroxy-7-chloroquinoline-3-carboxylic acid ethyl ester
  • ethyl 7-chloro-4-oxo-1H-quinoline-3-carboxylate
  • Ethyl7-chloro-4-hydroxy-3-quinolinecarboxylate
CAS:
16600-22-9
MF:
C12H10ClNO3
MW:
251.67
Mol File:
16600-22-9.mol
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7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER Chemical Properties

Melting point:
296-298℃
Boiling point:
366.8±37.0 °C(Predicted)
Density 
1.386
storage temp. 
Sealed in dry,Room Temperature
pka
2.18±0.50(Predicted)
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Safety Information

HS Code 
2933499090
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7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER Usage And Synthesis

Chemical Properties

Crystalline compounds. Melting point 297 ℃.

Uses

Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate can be used as an intermediate of chloroquine.

Synthesis

Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate can be obtained by heating and condensing m-chloroaniline and triethyl orthoformate, then condensing with diethyl malonate with the participation of boron trifluoride, and finally heating and cyclizing in paraffin oil.

7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTERSupplier

Shanghai Hanhong Scientific Co.,Ltd.
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SynAsst Chemical.
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Amadis Chemical Company Limited
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